STRINGSTRING
bgcn bgcn cona cona bam bam hts hts CG14073 CG14073 CG13527 CG13527 CG17781 CG17781 CG12826 CG12826 AP-2mu AP-2mu c(2)M c(2)M Sxl Sxl
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bgcnBenign gonial cell neoplasm (bgcn) encodes an RNA-binding protein involved in germline stem cell lineage differentiation. It forms a translational repressor complex with the product of bam in ovaries and with the products of bam and tut in testis. (1215 aa)    
Predicted Functional Partners:
cona
IP08467p; Corona (cona) encodes a component of the synaptonemal complex that is required for many meiotic processes, including homolog pairing, recombination, and chromosome segregation at meiosis I.
   
  
 0.865
bam
Bag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway.
   
   0.865
hts
Hu li tai shao (hts) encodes an adducin homolog that is associated with the plasma membrane cytoskeleton, fusome and oocyte ring canals. It has essential functions in muscle, nerve and other tissues, and is required for fertility in males and females; Belongs to the aldolase class II family. Adducin subfamily.
   
  
 0.835
CG14073
Uncharacterized protein, isoform B; It is involved in the biological process described with: wing disc dorsal/ventral pattern formation.
    
 
 0.809
CG13527
Uncharacterized protein, isoform B; It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
   
  
 0.800
CG17781
FI03705p.
      
 0.795
CG12826
Uncharacterized protein.
      
 0.795
AP-2mu
Adaptor Protein complex 2, mu subunit (AP-2mu) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization.
    
 
 0.671
c(2)M
Crossover suppressor on 2 of Manheim (c(2)M) encodes a Kleisin family member in the cohesin proteins. It interacts with cohesins, such as the products of SMC1 and SMC3, to promote synaptonemal complex assembly in female meiosis.
      
 0.667
Sxl
Protein sex-lethal; Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex- determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific [...]
   
 
 0.661
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.