STRINGSTRING
Bro Bro Cul5 Cul5 EloC EloC run run EloB EloB Bsg25A Bsg25A CG6962 CG6962 Elba3 Elba3 lz lz Pif2 Pif2 Bgb Bgb
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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textmining
co-expression
protein homology
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BroBrother (Bro) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bgb in embryonic segmentation. (213 aa)    
Predicted Functional Partners:
Cul5
FI20194p1; Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction; Belongs to the cullin family.
    
 
 0.898
EloC
Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto.
    
 
 0.889
run
Segmentation protein Runt; Runt (run) encodes an alpha-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It contributes to axon guidance, dendrite morphogenesis and germ-band extension.
   
 
 0.887
EloB
Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto.
    
 
 0.860
Bsg25A
Early boundary activity protein 1; The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba1 may act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression.
   
    0.843
CG6962
LD28817p; Sphingomyelin phosphodiesterase D activity. It is involved in the biological process described with: ceramide biosynthetic process; glycerophospholipid catabolic process; sphingomyelin catabolic process.
      
 0.834
Elba3
Early boundary activity protein 3; The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba3 lacks DNA-binding activity and plays the role of an adapter protein, bringing Elba1 and 2 together, thereby establishing a complex that recognizes the asymmetric sequence motif through the BEN domains of Elba1 and 2.
   
    0.703
lz
Protein lozenge; Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory s [...]
    
 
 0.672
Pif2
Protein binding.
      
 0.668
Bgb
Big brother (Bgb) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bro in embryonic segmentation; Belongs to the CBF-beta family.
  
 
0.645
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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