STRINGSTRING
Cse1 Cse1 ebo ebo Kap-alpha1 Kap-alpha1 emb emb Kap-alpha3 Kap-alpha3 alphaKap4 alphaKap4 Ran Ran Ran-like Ran-like Pen Pen CG15443 CG15443 Ranbp21 Ranbp21
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
Cse1Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). (975 aa)    
Predicted Functional Partners:
ebo
Ellipsoid body open (ebo) encodes a protein that complexes with actin, the product of chic, and Ran-GTPase to mediate actin nuclear export. Loss of ebo during development results in defects in the ellipsoid body of the central complex. In the adult brain, accumulation of nuclear actin results in the inhibition of the product of bs and subsequent loss of visual orientation memory.
   
 
 0.984
Kap-alpha1
Importin subunit alpha; Karyopherin alpha1 (Kap-alpha1) encodes a protein that is involved in spermatogenesis and the nuclear import of the product of yki.
   
 
 0.925
emb
Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut.
   
 
 0.919
Kap-alpha3
Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family.
   
 
 0.908
alphaKap4
Importin subunit alpha; Nuclear import signal receptor activity; nuclear localization sequence binding. It is involved in the biological process described with: proteasome assembly; NLS-bearing protein import into nucleus; Belongs to the importin alpha family.
   
 
 0.905
Ran
GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...]
   
 
 0.904
Ran-like
GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.
   
 
 0.892
Pen
Importin subunit alpha; Pendulin (Pen) encodes a member of the Importin-alpha protein family, an essential adaptor in the Ran-GTP nuclear transport cycle binding a cargo protein to the nuclear import receptor encoded by Fs(2)Ket. In addition to nuclear protein import, the product of Pen is involved in centrosome duplication, mitotic spindle dynamics, nuclear envelope assembly, ring canal formation in the female germline, geotaxic behaviour and perception of pain.
   
 
 0.846
CG15443
RH51096p.
   
 
 0.811
Ranbp21
Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus.
   
 
 0.804
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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