STRINGSTRING
ari-1 ari-1 Ubc10 Ubc10 Prx5 Prx5 Nedd8 Nedd8 RpS27A RpS27A CG43133 CG43133 Cul6 Cul6 Cul3 Cul3 CG17030 CG17030 Ubc84D Ubc84D Cul1 Cul1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ari-1E3 ubiquitin-protein ligase ariadne-1; Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10. Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Appears to function, at least partially redundantly, with the RBR E3 ligase family mem [...] (503 aa)    
Predicted Functional Partners:
Ubc10
Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the [...]
    
 0.963
Prx5
Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis.
 
      0.833
Nedd8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
    
 
 0.812
RpS27A
Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...]
    
 
 0.798
CG43133
Uncharacterized protein.
      
 0.793
Cul6
Cullin 6; Ubiquitin-protein transferase activity; ubiquitin protein ligase binding; Belongs to the cullin family.
   
 
 0.790
Cul3
Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family.
   
 
 0.787
CG17030
AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process.
    
 0.782
Ubc84D
Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.
    
 0.782
Cul1
Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...]
   
 
 0.777
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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