STRINGSTRING
hspa8 hspa8 hsp90aa1.1 hsp90aa1.1 bag3 bag3 dnaja1 dnaja1 dnajb6a dnajb6a hspb8 hspb8 hsp90ab1 hsp90ab1 dnajb1a dnajb1a dnaja2a dnaja2a hspb1 hspb1 E7FDL8_DANRE E7FDL8_DANRE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hspa8Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (649 aa)    
Predicted Functional Partners:
hsp90aa1.1
Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...]
 
 
 
 0.980
bag3
BCL2-associated athanogene 3.
   
 0.956
dnaja1
DnaJ heat shock protein family (Hsp40) member A1.
 
 0.944
dnajb6a
DnaJ heat shock protein family (Hsp40) member B6a.
 
 0.935
hspb8
Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.
   
 0.935
hsp90ab1
Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]
 
 
 0.931
dnajb1a
DnaJ heat shock protein family (Hsp40) member B1a.
 
 0.918
dnaja2a
DnaJ heat shock protein family (Hsp40) member A2a.
 
 0.909
hspb1
Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.
   
 0.894
E7FDL8_DANRE
J domain-containing protein.
 
 0.883
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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