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dapE dapE dapF dapF dapD dapD dapC dapC dapA dapA argD argD Rv1178 Rv1178 lysA lysA dapB dapB asd asd ask ask
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Predicted Interactions
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textmining
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dapEProbable succinyl-diaminopimelate desuccinylase DapE; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid. (354 aa)    
Predicted Functional Partners:
dapF
Probable diaminopimelate epimerase DapF (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
 
 
 0.997
dapD
Tetrahydrodipicolinate N-succinyltransferase DapD; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
 
  
 0.996
dapC
Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at); Involved in the lysine biosynthetic pathways. It catalyzes the transfer of an amino group from L-glutamate to N-succinyl-2-l- amino-6-oxoheptanedioate (N-succinyl-2-l-amino-6-ketopimelate) in a PLP-dependent reaction, yielding as products N-succinyl-l-2,6- diaminoheptanedioate (N-succinyl-diaminopimelate) and 2-oxoglutarate (Probable); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.988
dapA
Probable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Belongs to the DapA family.
  
  
 0.950
argD
Rv1655, (MTCY06H11.20), len: 400 aa. Probable argD,Acetylornithine aminotransferase, similar to ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E(): 0,(38.6% identity in 404 aa overlap), contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases.
  
 
 0.911
Rv1178
Rv1178, (MTV005.14), len: 362 aa. Probable aminotransferase, weak similarity to many aspartate aminotransferases e.g. Q55679|D64000 SLL0006 aspartate aminotransferase from Synechocystis sp. (394 aa), FASTA scores: opt: 218, E(): 1.3e-25, (32.5% identity in 379 aa overlap). Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. Also similar to Mycobacterium tuberculosis aminotransferases Rv2294,Rv0075, etc.
 
  
 0.903
lysA
Diaminopimelate decarboxylase LysA (DAP decarboxylase); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M.tuberculosis in the host.
 
  
 0.857
dapB
Dihydrodipicolinate reductase DapB (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.
 
 
 0.850
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. Is essential for the growth and pathogenicity of M.tuberculosis, and for the generation of the bacterial cell wall ; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
  
 0.827
ask
Aspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha); Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family.
 
  
 0.800
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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