STRINGSTRING
top6B top6B top6A top6A dys dys rtcB rtcB eif5a eif5a rps8e rps8e dnaG dnaG priS priS priL priL SiRe_1114 SiRe_1114 SiRe_1121 SiRe_1121
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
top6BDNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (530 aa)    
Predicted Functional Partners:
top6A
DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
 
 
 0.999
dys
Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
 
     0.775
rtcB
Archaeal RNA splicing ligase; Belongs to the RtcB family.
       0.726
eif5a
Translation initiation factor eIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
    0.676
rps8e
Ribosomal protein S8e.
  
    0.666
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
   
 0.659
priS
DNA primase small subunit, PriSL; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synt [...]
  
   
 0.576
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
   
 0.562
SiRe_1114
Pseudouridylate synthase-like protein.
 
     0.556
SiRe_1121
Conserved hypothetical protein.
       0.553
Your Current Organism:
Sulfolobus islandicus
NCBI taxonomy Id: 930945
Other names: S. islandicus REY15A, Sulfolobus islandicus REY15A, Sulfolobus islandicus str. REY15A, Sulfolobus islandicus strain REY15A
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