node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGMAT | ALDH18A1 | ENSBTAP00000067134 | ENSBTAP00000015703 | Agmatinase; Belongs to the arginase family. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.501 |
AGMAT | ARG1 | ENSBTAP00000067134 | ENSBTAP00000016461 | Agmatinase; Belongs to the arginase family. | Arginase-1. | 0.490 |
AGMAT | ARG2 | ENSBTAP00000067134 | ENSBTAP00000053934 | Agmatinase; Belongs to the arginase family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.526 |
AGMAT | ASL | ENSBTAP00000067134 | ENSBTAP00000074023 | Agmatinase; Belongs to the arginase family. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.842 |
AGMAT | ASS1 | ENSBTAP00000067134 | ENSBTAP00000072835 | Agmatinase; Belongs to the arginase family. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.717 |
AGMAT | NAGS | ENSBTAP00000067134 | ENSBTAP00000021616 | Agmatinase; Belongs to the arginase family. | N-acetylglutamate synthase. | 0.562 |
AGMAT | OAT | ENSBTAP00000067134 | ENSBTAP00000009097 | Agmatinase; Belongs to the arginase family. | Ornithine aminotransferase, mitochondrial. | 0.946 |
AGMAT | ODC1 | ENSBTAP00000067134 | ENSBTAP00000005575 | Agmatinase; Belongs to the arginase family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.851 |
AGMAT | OTC | ENSBTAP00000067134 | ENSBTAP00000001947 | Agmatinase; Belongs to the arginase family. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.890 |
ALDH18A1 | AGMAT | ENSBTAP00000015703 | ENSBTAP00000067134 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Agmatinase; Belongs to the arginase family. | 0.501 |
ALDH18A1 | ALDH4A1 | ENSBTAP00000015703 | ENSBTAP00000059236 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | 0.986 |
ALDH18A1 | ARG1 | ENSBTAP00000015703 | ENSBTAP00000016461 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Arginase-1. | 0.475 |
ALDH18A1 | ARG2 | ENSBTAP00000015703 | ENSBTAP00000053934 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.463 |
ALDH18A1 | ASL | ENSBTAP00000015703 | ENSBTAP00000074023 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.729 |
ALDH18A1 | ASS1 | ENSBTAP00000015703 | ENSBTAP00000072835 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.749 |
ALDH18A1 | NAGS | ENSBTAP00000015703 | ENSBTAP00000021616 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | N-acetylglutamate synthase. | 0.679 |
ALDH18A1 | OAT | ENSBTAP00000015703 | ENSBTAP00000009097 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine aminotransferase, mitochondrial. | 0.995 |
ALDH18A1 | ODC1 | ENSBTAP00000015703 | ENSBTAP00000005575 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.475 |
ALDH18A1 | OTC | ENSBTAP00000015703 | ENSBTAP00000001947 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.429 |
ALDH4A1 | ALDH18A1 | ENSBTAP00000059236 | ENSBTAP00000015703 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.986 |