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surE surE slr0302 slr0302 hypE hypE slr1854 slr1854 thiE thiE moeB moeB thiO/thiG thiO/thiG sll1383 sll1383 thiC thiC thiL thiL slr0021 slr0021
"thiE" - Thiamin biosynthetic bifunctional enzyme in Synechocystis sp. PCC6803
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thiEThiamin biosynthetic bifunctional enzyme; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (343 aa)    
Predicted Functional Partners:
thiL
Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (364 aa)
 
  0.995
thiO/thiG
ThiG protein; Catalyzes the FAD-dependent oxidative deamination of glycine. Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (By similarity) (656 aa)
 
   
  0.982
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (459 aa)
 
 
  0.946
moeB
Molybdopterin biosynthesis protein MoeB (392 aa)
 
   
  0.866
hypE
Hydrogenase expression/formation protein HypE (345 aa)
       
    0.781
surE
Stationary-phase survival protein SurE homolog; Nucleotidase that shows phosphatase activity on nucleoside 5’-monophosphates (275 aa)
   
 
    0.774
slr0302
PleD gene product homolog (768 aa)
   
 
  0.723
slr0021
Protease IV (277 aa)
   
   
    0.700
sll1383
Probable myo-inositol-1-monophosphatase (287 aa)
   
 
  0.699
slr1854
Hypothetical protein (198 aa)
       
    0.699
Your Current Organism:
Synechocystis sp. PCC6803
NCBI taxonomy Id: 1148
Other names: Aphanocapsa sp. (strain N-1), Aphanocapsa sp. N-1, S. sp. PCC 6803, Synechocystis, Synechocystis PCC6803, Synechocystis sp. (ATCC 27184), Synechocystis sp. (PCC 6803), Synechocystis sp. (strain PCC 6803), Synechocystis sp. ATCC 27184, Synechocystis sp. PCC 6803, Synechocystis sp. PCC 6803 A, Synechocystis sp. PCC 6803 B, Synechocystis sp. PCC6803
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