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ilvD ilvD leuA leuA ilvC ilvC ilvG ilvG nifJ nifJ cimA cimA ilvH ilvH ilvA ilvA ilvB ilvB leuB leuB pdhB pdhB
"ilvH" - Acetolactate synthase in Synechocystis sp. PCC6803
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvHAcetolactate synthase (172 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase (331 aa)
 
  0.998
ilvG
Acetolactate synthase 3 catalytic subunit (621 aa)
 
  0.997
ilvB
Acetolactate synthase (550 aa)
 
  0.997
ilvA
L-threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (508 aa)
 
 
  0.992
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) (362 aa)
 
 
  0.989
cimA
Alpha-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate (547 aa)
 
 
  0.927
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (533 aa)
   
 
  0.923
ilvD
Dihydroxyacid dehydratase (561 aa)
 
 
  0.908
nifJ
Pyruvate oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1199 aa)
   
 
    0.903
pdhB
Pyruvate dehydrogenase E1 beta subunit (324 aa)
     
 
    0.834
Your Current Organism:
Synechocystis sp. PCC6803
NCBI taxonomy Id: 1148
Other names: Aphanocapsa sp. (strain N-1), Aphanocapsa sp. N-1, S. sp. PCC 6803, Synechocystis, Synechocystis PCC6803, Synechocystis sp. (ATCC 27184), Synechocystis sp. (PCC 6803), Synechocystis sp. (strain PCC 6803), Synechocystis sp. ATCC 27184, Synechocystis sp. PCC 6803, Synechocystis sp. PCC 6803 A, Synechocystis sp. PCC 6803 B, Synechocystis sp. PCC6803
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