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STRINGSTRING
ESP1 ESP1 SMC6A SMC6A EDP06267 EDP06267 EDP04084 EDP04084 SMC2 SMC2 SMC4 SMC4 SMC5B SMC5B TOP2 TOP2 TOP1 TOP1 EDP09315 EDP09315 EDP05135 EDP05135
"TOP2" - DNA topoisomerase II in Chlamydomonas reinhardtii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP2DNA topoisomerase II; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1167 aa)    
Predicted Functional Partners:
EDP06267
Chromosome condensation complex protein (2665 aa)
     
   
  0.993
TOP1
DNA topoisomerase I (586 aa)
     
 
  0.990
ESP1
Separase, cell cycle protease (2337 aa)
     
 
  0.987
SMC4
Structural maintenance of chromosomes protein 4 (1237 aa)
     
 
  0.985
EDP04084
Predicted protein (1377 aa)
     
   
  0.984
SMC2
Structural maintenance of chromosomes protein 2 (1165 aa)
     
 
  0.984
EDP09315
High mobility group protein (552 aa)
     
 
  0.980
EDP05135
SNF2 superfamily protein (1610 aa)
     
  0.976
SMC5B
Structural maintenance of chromosomes protein 5B (1124 aa)
     
 
  0.976
SMC6A
Structural maintenance of chromosomes protein 6A (1207 aa)
     
 
  0.973
Your Current Organism:
Chlamydomonas reinhardtii
NCBI taxonomy Id: 3055
Other names: C. reinhardtii, Chlamydomonadaceae, Chlamydomonadales, Chlamydomonas, Chlamydomonas reinhardtii, Chlamydomonas reinhardtii P.A.Dangeard, Chlamydomonas smithii, Chlamydomonas smithii R.W.Howshaw & H.Ettl, Chlorophyceae, Volvocales, Volvocida
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