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CYCA1;1 CYCA1;1 CYCA2;1 CYCA2;1 CYCA2;4 CYCA2;4 CDC2 CDC2 CYC3B CYC3B CYCA3;1 CYCA3;1 CYCA2;3 CYCA2;3 WEE1 WEE1 CYCA3;4 CYCA3;4 CYCA3;3 CYCA3;3 CYCA3;2 CYCA3;2
WEE1 kinase homolog in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
WEE1WEE1 kinase homolog; Cell cycle regulatory kinase that is not rate-limiting for cycle progression under normal growth conditions. Transcriptionally activated upon DNA stress or damage in an ATR- or ATM-dependent manner. Once activated, inhibits plant growth by arresting dividing cells in the G2 phase before proceeding into mitosis. Down-regulates CDKA-1 and CDKD-2 by tyrosine phosphorylation. May target principally CDKA-1 (500 aa)    
Predicted Functional Partners:
CYCA1;1
Cyclin A1;1 (460 aa)
     
  0.998
CYCA2;1
Cyclin a2;1; May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication (437 aa)
     
  0.998
CDC2
Cell division control 2; Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis (294 aa)
     
0.998
CYCA3;1
Cyclin A3-1 (355 aa)
     
  0.998
CYCA3;2
cyclin-A3-2 (372 aa)
     
  0.997
CYCA3;3
Cyclin A3;3 (327 aa)
     
  0.997
CYCA2;3
CYCLIN A2;3; Negatively regulates endocycles and acts as a regulator of ploidy levels in endoreduplication (450 aa)
     
  0.997
CYC3B
cyclin-A2-2 (436 aa)
     
  0.997
CYCA2;4
Cyclin A2;4 (461 aa)
     
  0.997
CYCA3;4
CYCLIN A3;4 (370 aa)
     
  0.996
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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