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AT1G42470 AT1G42470 PSD3 PSD3 NPC1 NPC1 PLDALPHA1 PLDALPHA1 NPC5 NPC5 PI-4KBETA1 PI-4KBETA1 LPLAT1 LPLAT1 NPC3 NPC3 AT3G10550 AT3G10550 NPC4 NPC4 VPS34 VPS34
"NPC1" - Phospholipase C in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
NPC1Phospholipase C (533 aa)    
Predicted Functional Partners:
AT1G42470
Patched family protein (1272 aa)
     
   
  0.960
PI-4KBETA1
Phosphatidylinositol 4-kinase beta 1; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5-trisphosphate. Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB2, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB2 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway (1121 aa)
     
 
  0.926
VPS34
Vacuolar protein sorting 34 (814 aa)
     
 
  0.922
PSD3
Phosphatidylserine decarboxylase 3; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Contributes only to a minor proportion of PtdEtn production (635 aa)
     
 
    0.914
PLDALPHA1
Phospholipase D alpha 1; Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action and response to stress, characterized by acidification of the cell (PubMed-9437863). Involved in wound induction of jasmonic acid (PubMed-11090221). May be involved in membrane lipid remodeling (PubMed-11239826). Probably involved in freezing tolerance by modulating the cold-responsive genes and accumulation of osmolytes (PubMed-16949955). Can use phosphatidylcholine (PC [...] (810 aa)
         
  0.913
LPLAT1
Lysophospholipid acyltransferase 1; Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphat [...] (462 aa)
     
 
    0.906
AT3G10550
Myotubularin 1; Phosphatase with phosphoinositide 3’-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Required for recovery after water deprivation, via the accumulation of PtdIns5P upon dehydration; high PtdIns5P levels mediate ATX1 cytoplasmic localization, thus down-regulating the expression of ATX1- dependent genes. Confers sensitivity to soil-wat [...] (840 aa)
     
 
    0.906
NPC5
Non-specific phospholipase C5; Non-specific phospholipase C (PLC) which assumes minor PLC activity during inorganic phosphate starvation. Can hydrolyze both phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Required for normal accumulation of digalactosyldiacylglycerol (DGDG) during phosphate limitation and may contribute to the conversion of phospholipids to diacylglycerol, the substrate for galactolipid synthesis (521 aa)
   
   
0.905
NPC3
Non-specific phospholipase C3; Possesses specific phosphatase activity toward lysophosphatidic acid (LPA) in vitro. Does not show phospholipase C activity. May play a role in signal transduction and storage lipid synthesis. May be involved in brassinolide-mediated signaling in root development (523 aa)
   
   
0.905
NPC4
Phospholipase C; Non-specific phospholipase C (PLC) which assumes major PLC activity during inorganic phosphate starvation. Substrate preference is phosphatidylcholine (PC), but can also hydrolyze phosphatidylethanolamine (PE) with lower efficiency. Has no activity toward phosphatidic acid (PA). Plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. May be required for lipid-derived signaling molecules that positively modulate abscisic acid (ABA) response and promote plant tolerance to dro [...] (538 aa)
   
   
0.905
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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