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RFC2 RFC2 RPA70D RPA70D RPA70B RPA70B EMB2775 EMB2775 EMB2780 EMB2780 POLH POLH EMB1968 EMB1968 PCNA1 PCNA1 POLD2 POLD2 RPA2 RPA2 EMB2810 EMB2810
"PCNA1" - Proliferating cellular nuclear antigen 1 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
PCNA1Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (263 aa)    
Predicted Functional Partners:
EMB2775
EMBRYO DEFECTIVE 2775; May be involved in DNA replication and thus regulate cell proliferation (354 aa)
   
  0.999
EMB1968
Embryo defective 1968; May be involved in DNA replication and thus regulate cell proliferation (341 aa)
   
  0.999
POLD2
DNA polymerase delta subunit 2; The function of the small subunit is not yet clear (441 aa)
     
  0.999
EMB2810
Replication factor C subunit 3; Functions in cell replication and proliferation. May be involved in chromatin assembly and remodeling. Plays a role in the negative control of pathogenesis-related gene expression and systemic acquired resistance (SAR) (369 aa)
   
  0.999
RFC2
Replication factor C 2; May be involved in DNA replication and thus regulate cell proliferation (333 aa)
   
  0.999
EMB2780
DNA polymerase delta subunit 1; This polymerase possesses two enzymatic activities- DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’- to 5’-direction (1112 aa)
     
  0.999
RPA2
Replicon protein A2; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Required fo cell division in meristems. Involved in the maintenance of transcriptional epigenetic gene silencing (TGS) at specific loci (including some transposons) by regulating histone H3 acetylation, ’Lys-4’ and ’Lys-9’ methylation (279 aa)
     
  0.999
POLH
Y-family DNA polymerase H; Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV- induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5’-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Ex [...] (672 aa)
     
  0.999
RPA70B
RPA70-kDa subunit B; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity). Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity) (604 aa)
     
  0.999
RPA70D
Replication factor-A protein 1-related; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity) (629 aa)
     
  0.999
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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