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AT3G09100 AT3G09100 HIRA HIRA GC6 GC6 AT5G01290 AT5G01290 AT1G75600 AT1G75600 ATRX ATRX AT5G28210 AT5G28210 HMG HMG TOPII TOPII SUVH4 SUVH4 MPA24.5 MPA24.5
"ATRX" - DEAD-like helicase domain-containing protein in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ATRXDEAD-like helicase domain-containing protein; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3- containing nucleosomes (By similarity). Involved in DNA repair of gamma-irradiation-mediated damages (PubMed-16547115) (1479 aa)    
Predicted Functional Partners:
HMG
High mobility group; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the n [...] (646 aa)
     
  0.967
TOPII
Topoisomerase II; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1473 aa)
     
  0.961
GC6
Golgin candidate 6; Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus. Functions in the anterograde transport of storage protein precursors from the endoplasmic reticulum (ER) to the Golgi complex (914 aa)
     
      0.959
AT5G01290
mRNA capping enzyme family protein (657 aa)
     
      0.887
HIRA
Protein HIRA/HIR1; Histone chaperone involved in maintining knox genes silencing throughout leaf development. May be involved in heterochromatic and euchromatic gene silencing (By similarity) (1058 aa)
     
 
  0.881
AT1G75600
Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) (136 aa)
       
 
  0.862
AT3G09100
mRNA capping enzyme-like protein (672 aa)
     
      0.859
SUVH4
SU(VAR)3-9 homolog 4; Histone methyltransferase. Methylates ’Lys-9’ of histone H3. H3 ’Lys-9’ methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements (624 aa)
   
  0.854
AT5G28210
mRNA capping enzyme family protein (625 aa)
       
      0.840
MPA24.5
BARELY ANY MERISTEM 1; Necessary for male gametophyte development, as well as ovule specification and function. Involved in cell-cell communication process required during early anther development, and regulating cell division and differentiation to organize cell layers. Required for the development of high-ordered vascular strands within the leaf and a correlated control of leaf shape, size and symmetry. May regulate the CLV1-dependent CLV3-mediated signaling in meristems maintenance (1003 aa)
   
 
  0.812
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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