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ICU2 ICU2 AT1G18340 AT1G18340 EMB2780 EMB2780 POLD2 POLD2 PCNA1 PCNA1 POLD4 POLD4 POLD3 POLD3 PCNA2 PCNA2 AT3G42830 AT3G42830 CAK4 CAK4 DDB1B DDB1B
"POLD4" - Polymerase delta 4 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
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Textmining
[Homology]
Score
POLD4Polymerase delta 4 (124 aa)    
Predicted Functional Partners:
EMB2780
DNA polymerase delta subunit 1; This polymerase possesses two enzymatic activities- DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’- to 5’-direction (1112 aa)
       
  0.987
POLD2
DNA polymerase delta subunit 2; The function of the small subunit is not yet clear (441 aa)
       
  0.981
ICU2
INCURVATA2; Polymerase alpha in a complex with DNA primase is a replicative polymerase (1524 aa)
       
  0.980
PCNA1
Proliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (263 aa)
     
  0.964
PCNA2
Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (By similarity). May be involved in UV resistance (264 aa)
     
  0.959
POLD3
DNA-directed DNA polymerase (509 aa)
       
  0.953
CAK4
CDK-activating kinase 4; Forms a stable complex with cyclin CYCH1-1 that phosphorylates human CDK2 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II (348 aa)
         
  0.931
AT1G18340
Transcription initiation factor TFIIH subunit H3; Component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA (301 aa)
     
 
    0.927
AT3G42830
RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate (By similarity) (115 aa)
     
 
    0.926
DDB1B
DNA damage-binding protein 1b; Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness (By similarity). Plays a role in DNA repair by forming with DDB2 the UV-damaged DNA-binding protein complex (UV-DDB) (By similarity) (1088 aa)
     
 
    0.925
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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