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AT2G28620 AT2G28620 ATK5 ATK5 AT5G60930 AT5G60930 HIK HIK ATK1 ATK1 SYP111 SYP111 MAD2 MAD2 TOPII TOPII EB1C EB1C PLE PLE NP3 NP3
"HIK" - HINKEL in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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HIKHINKEL; Probable plus end-directed motor protein that functions in a MAP kinase signaling pathway (ANP1-MKK6-MPK4), which is essential for somatic cell cytokinesis, especially for the cell- plate formation and its expansion. Regulates the activity and the localization of ANP1, probably by association through the non- catalytic region of the kinase. Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis (974 aa)    
Predicted Functional Partners:
SYP111
Syntaxin of plants 111; Involved in cytokinesis. Acts as a cell plate-specific syntaxin, required for the fusion of vesicles at the plane of cell division (310 aa)
     
 
  0.975
ATK5
Kinesin 5; Kinesin that supports microtubule movement in an ATP- dependent manner and that functions as a minus-end directed motor as well as a plus-end tracking protein. During mitosis, is involved in early spindle assembly. Participates in the capture of antiparallel interpolar microtubules and helps in generating force to coalign microtubules (790 aa)
     
0.958
PLE
PLEIADE; Microtubule-associated protein that plays a critical role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs. Essential for the cytokinesis, especially in roots, by maintaining the integrity of the overlapped microtubules in the phragmoplast. Required during root morphogenesis. Needed for giant cell development during root knot nematode infection, where cytokinesis is initiated but not completed (707 aa)
     
 
  0.949
AT5G60930
Kinesin family member 4/7/21/27; Kinesin-like motor protein involved in the control of the oriented deposition of cellulose microfibrils (1294 aa)
     
0.921
MAD2
MITOTIC ARREST-DEFICIENT 2; Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (209 aa)
     
 
  0.909
NP3
NPK1-related protein kinase 3; Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1 (651 aa)
     
 
  0.900
ATK1
Kinesin 1; Kinesin that supports microtubule movement in an ATP- dependent manner and has a minus-end directed polarity. Plays a crucial role in spindle morphogenesis in male Arabidopsis meiosis. In mitosis, is required for normal microtubule accumulation at the spindle poles during prophase and may play a role in spindle assembly during prometaphase (793 aa)
     
0.890
EB1C
End binding protein 1C; Plant-specific EB1 subtype that functions preferentially at early stages of plant mitosis by regulating spindle positioning and chromosome segregation. Accumulates in the prophase nucleus and is required to maintain spindle bipolarity during premetaphase and/or metaphase and for efficient segregation of chromosomes at anaphase. May play a role in the dynamics of microtubule network in elongating pollen tubes (329 aa)
     
 
  0.890
TOPII
Topoisomerase II; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1473 aa)
     
   
  0.886
AT2G28620
P-loop containing nucleoside triphosphate hydrolase-like protein; Responsible for microtubule translocation. May be important for the organization of phragmoplast-specific arrays of microtubules (By similarity). Plays an essential role in stabilizing the mitotic spindle (PubMed-17652157). Required during mitotic cytokinesis (PubMed-26745275) (1042 aa)
     
0.886
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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