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LOB LOB PRE1 PRE1 BIM3 BIM3 CES CES BEE1 BEE1 AIF1 AIF1 BIM1 BIM1 BIN2 BIN2 BES1 BES1 BZR1 BZR1 DET2 DET2
"BEE1" - BR enhanced expression 1 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
BEE1BR enhanced expression 1; Positive regulator of brassinosteroid signaling (260 aa)    
Predicted Functional Partners:
BIM3
Transcription factor BIM3; Positive brassinosteroid-signaling protein (298 aa)
           
  0.670
BIM1
Transcription factor BIM1; Positive brassinosteroid-signaling protein. Transcription factor that bind specifically to the DNA sequence 5’-CANNTG-3’(E box). Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BZR2/BES1. Does not itself activate transcription but enhances BZR2/BES1-mediated target gene activation (532 aa)
           
  0.633
LOB
LATERAL ORGAN BOUNDARIES; Not known; ectopic expression of LOB leads to alterations in the size and shape of leaves and floral organs and causes male and female sterility (186 aa)
       
      0.612
BES1
BRI1-EMS-SUPPRESSOR 1; Positive brassinosteroid-signaling protein. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5’-CANNTG-3’(E box) through its N-terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C-terminal domain is probably involved in transcriptional activation (357 aa)
           
  0.603
AIF1
Transcription factor bHLH150; Atypical bHLH transcription factor probably unable to bind DNA. Negatively regulates brassinosteroid signaling (211 aa)
           
  0.602
PRE1
PACLOBUTRAZOL RESISTANCE1; Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. Binds IBH1, forming a pair of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation. Regulates light responses by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. May have a regulatory role in various aspects of gibberellin-dependent growth a [...] (92 aa)
           
  0.598
BZR1
BRASSINAZOLE-RESISTANT 1; Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5’-CGTG(T/C)G-3’ in gene promoter. Regulates positively the brassinosteroid-signaling pathway. Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2) (336 aa)
           
  0.586
CES
CESTA (223 aa)
       
 
0.584
DET2
DE-ETIOLATED 2; Involved in a reduction step in the biosynthesis of the plant steroid, brassinolide; acts at the second step in brassinolide biosynthesis in the 5alpha-reduction of (24R)- 24- methylcholest-4-en-3-one, which is further modified to form campestanol. Can use progesterone, testosterone, androstenedione and campestenone as substrate (262 aa)
           
  0.556
BIN2
BRASSINOSTEROID-INSENSITIVE 2; Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5 (380 aa)
           
  0.554
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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