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ELC ELC AT4G34660 AT4G34660 ELC-Like ELC-Like VPS24.1 VPS24.1 VPS20.2 VPS20.2 VPS2.2 VPS2.2 VPS2.1 VPS2.1 AT1G20110 AT1G20110 SNF7.1 SNF7.1 VPS37-1 VPS37-1 IRT1 IRT1
"AT1G20110" - RING/FYVE/PHD zinc finger-containing protein in Arabidopsis thaliana
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AT1G20110RING/FYVE/PHD zinc finger-containing protein; Endosomal sorting complex required for transport (ESCRT) component regulating multivesicular body (MVB) protein sorting and plant growth (PubMed-25438943). Required for the formation of intra-luminal vesicles (ILVs)in MVBs (PubMed-25438943). Binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin (PubMed-25438943, PubMed-24843126). Controls IRT1 recycling to the plasma membrane and impacts the polar delivery of this transporter to the outer plasma membrane domain (PubMed-24843126). Regulates ubiquitin-dependent membrane protein degra [...] (601 aa)    
Predicted Functional Partners:
ELC
Protein ELC; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) Mediates the association to the ESCRT-0 complex. May control nuclear division through the microtubule cytoskeleton (398 aa)
     
    0.889
ELC-Like
ELCH-like; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex (By similarity) (368 aa)
       
    0.876
AT4G34660
SH3 domain-containing protein; Regulator for autophaosome formation and/or maturation (PubMed-24249832, Ref.9). Binds phosphatidylinositol 3-phosphate (PubMed-24249832) (368 aa)
       
 
  0.853
IRT1
Fe(2+) transport protein 1; High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions (347 aa)
       
 
  0.752
VPS2.1
SNF7 family protein; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (225 aa)
     
 
    0.741
SNF7.1
SNF7 family protein; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (219 aa)
     
 
    0.736
VPS2.2
SNF7 family protein; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (222 aa)
         
    0.720
VPS24.1
SNF7 family protein; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (229 aa)
         
    0.720
VPS20.2
Vacuolar protein sorting-associated protein 20-2; Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity) (216 aa)
         
    0.720
VPS37-1
Modifier of rudimentary (Mod(r)) protein; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity) (217 aa)
         
    0.720
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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