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RSW3 RSW3 CGL1 CGL1 XYLT XYLT MNS1 MNS1 MNS2 MNS2 GMII GMII FUT11 FUT11 MNS3 MNS3 EBS1 EBS1 OS9 OS9 Hrd1A Hrd1A
"MNS3" - Alpha-mannosidase 3 in Arabidopsis thaliana
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Predicted Interactions
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textmining
co-expression
protein homology
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MNS3Alpha-mannosidase 3; Class I alpha-mannosidase essential for early N-glycan processing. Removes preferentially alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2). Involved in root development and cell wall biosynthesis (624 aa)    
Predicted Functional Partners:
CGL1
COMPLEX GLYCAN LESS 1; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Required for normal root growth and morphology (444 aa)
     
 
  0.968
RSW3
RADIAL SWELLING 3; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Essential for stable accumulation of the receptor EFR that determines the specific perception of bacterial elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Required for sustained activation of EFR-mediated signaling, but not receptor FLS2-mediated signaling elicited by the bacterial flagellin flg22 (921 aa)
     
 
  0.949
MNS2
Alpha-mannosidase 2; Class I alpha-mannosidase essential for early N-glycan processing. Progressively trim alpha-1,2-linked mannose residues. Produces Man(5)GlcNAc(2) from Man(8)GlcNAc(2), but only Man(6)GlcNAc(2) from Man(9)GlcNAc(2). Have difficulty acting on the terminal mannose of the b-branch. Involved in root development and cell wall biosynthesis (572 aa)
     
 
0.881
GMII
Alpha-mannosidase II; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Converts GlcNAcMan(5)GlcNAc(2) (Man5Gn) into GlcNAcMan(3)GlcNAc(2) (MGn) by sequential removal of two alpha1,6- and alpha1,3-linked mannose residues from the alpha1,6-mannose branch of the substrate. To a lesser extent, also able to cleave beta1,2-xylosylated Man5Gn-glycopeptide (Man5GnX-GP) and pyridylaminated substrates Man5Gn-PA and Man5GnX-PA, but not active towar [...] (1173 aa)
     
   
  0.851
MNS1
Alpha-mannosidase 1; Class I alpha-mannosidase essential for early N-glycan processing. Progressively trim alpha-1,2-linked mannose residues. Produces Man(5)GlcNAc(2) from Man(8)GlcNAc(2), but only Man(6)GlcNAc(2) from Man(9)GlcNAc(2). Have difficulty acting on the terminal mannose of the b-branch. Involved in root development and cell wall biosynthesis (560 aa)
         
0.814
EBS1
EMS-mutagenized bri1 suppressor 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Required for elongation factor Tu receptor (EFR), but not flagellin-sensing 2 (FLS2) signaling (1614 aa)
     
   
  0.786
OS9
OS9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Targets the misfolded LRR receptor kinase BRI1 and the misfolded receptor-like kinase EFR (282 aa)
           
  0.702
Hrd1A
Homolog of yeast Hrd1; Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3B (492 aa)
     
   
  0.696
FUT11
Fucosyltransferase 11; Involved in cell wall synthesis. Catalyzes alpha-1,3 glycosidic linkages (501 aa)
     
   
  0.693
XYLT
Beta-1,2-xylosyltransferase; Catalyzes beta-1,2 glycosidic linkages (534 aa)
     
   
  0.684
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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