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BIP1 BIP1 IRE1A IRE1A BIP3 BIP3 BIP2 BIP2 IRE1-1 IRE1-1 BI1 BI1 BZIP60 BZIP60 BZIP17 BZIP17 BZIP28 BZIP28 AT5G42050 AT5G42050 NAC062 NAC062
"BZIP60" - bZIP transcription factor 60 in Arabidopsis thaliana
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Predicted Interactions
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textmining
co-expression
protein homology
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BZIP60bZIP transcription factor 60; Transcription factor involved in the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Plays a role in plant immunity and abiotic stress responses (295 aa)    
Predicted Functional Partners:
BZIP28
Putative bZIP transcription factor; Transcriptional activator involved in ER stress responses. Functions as a stress sensor and transducer in ER stress signaling pathway. After proteolysis by SBT6.1 (S1P) and S2P, the N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones (PubMed-18156219, PubMed-18634751, PubMed-18849477, PubMed-20876872). Following ER stress, activates proteins involved in brassinosteroid (BR) signaling, which is required for stress acclimation and growth (PubMed-20876872) (675 aa)
     
 
  0.989
BZIP17
Basic helix-loop-helix domain-containing protein; Transcriptional activator involved in salt and osmotic stress responses. Functions as a stress sensor and transducer in a signaling pathway that resembles an ER stress response. Following salt stress, BZIP17 is cleaved by SBT6.1 (S1P) and S2P at the C- terminus and the N-terminal bZIP component is translocated to the nucleus, where it activates the expression of salt stress response genes (PubMed-17662035). Functions as a stress sensor and transducer in ER stress signaling pathway. ER stress induces proteolysis of BZIP17 by SBT6.1 (S1P) [...] (721 aa)
       
 
  0.985
BIP3
Binding protein 3; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and the general transcription factors (By similarity) (675 aa)
     
   
  0.961
NAC062
NAC domain containing protein 62; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (PubMed-20156199, PubMed-19947982). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant resistance to pathogen infection, incorporating cold signals into pathogen resistance responses (PubMed-19947982). Plays a regulatory role in abscisic acid (ABA)- mediated drough [...] (469 aa)
     
   
  0.906
IRE1A
Endoribonuclease/protein kinase IRE1-like protein; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses (841 aa)
     
   
  0.882
IRE1-1
Inositol requiring 1-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses. Required for ER stress-induced autophagy (887 aa)
           
  0.880
BIP2
Luminal-binding protein 2; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (668 aa)
           
  0.868
AT5G42050
DCD (Development and Cell Death) domain protein (349 aa)
     
   
  0.845
BIP1
Luminal-binding protein 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and the general transcription factors (669 aa)
           
  0.841
BI1
BAX inhibitor 1; Suppressor of apoptosis. Modulator of endoplasmic reticulum stress-mediated programmed cell death. Involved in methyl jasmonate-induced leaf senescence through regulating cytoplasmic calcium level (247 aa)
     
   
  0.812
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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