Full Link:
STRINGSTRING
PANK2 PANK2 AT5G02080 AT5G02080 HAL3A HAL3A COAD COAD COAB COAB ATHAL3B ATHAL3B AT4G35360 AT4G35360 ATCOAE ATCOAE PANK1 PANK1 AT2G17340 AT2G17340 AT2G17320 AT2G17320
"ATHAL3B" - Putative phosphopantothenoylcysteine decarboxylase in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATHAL3BPutative phosphopantothenoylcysteine decarboxylase; Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4’-phosphopantothenoylcysteine to 4’-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine (201 aa)    
Predicted Functional Partners:
PANK2
Pantothenate kinase 2; Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK1 (901 aa)
     
 
  0.996
COAD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4’- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4’-phosphopantothenoylcysteine as a substrate (176 aa)
       
  0.993
COAB
Phosphopantothenate--cysteine ligase 1; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine (317 aa)
       
  0.992
PANK1
Pantothenate kinase 1; Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK2 (383 aa)
     
 
  0.981
AT5G02080
Phosphopantothenate--cysteine ligase 2 (270 aa)
       
  0.947
ATCOAE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3’-hydroxyl group of dephosphocoenzyme A to form coenzyme A (232 aa)
   
 
  0.860
AT4G35360
Uncharacterized protein (367 aa)
           
  0.808
AT2G17340
Uncharacterized protein (367 aa)
           
  0.808
AT2G17320
Uncharacterized protein (361 aa)
           
  0.808
HAL3A
HAL3-like protein A; Involved in plant growth and salt and osmotic tolerance. Catalyzes the decarboxylation of 4’-phosphopantothenoylcysteine to 4’-phosphopantetheine, a key step in coenzyme A biosynthesis. The enzyme is also able to decarboxylate pantothenoylcysteine to pantothenoylcysteamine (209 aa)
   
   
0.803
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (3%)