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TBL10 TBL10 T21F11.18 T21F11.18 UPF3 UPF3 HD1 HD1 AT2G39260 AT2G39260 ERF3 ERF3 SAP18 SAP18 TPL TPL CID3 CID3 ETR1 ETR1 PEP PEP
"ERF3" - Ethylene-responsive transcription factor 3 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ERF3Ethylene-responsive transcription factor 3; Acts as a transcriptional repressor. Binds to the GCC- box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways and could also regulate other AtERFs (225 aa)    
Predicted Functional Partners:
UPF3
Smg-4/UPF3-like protein; Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nons [...] (484 aa)
     
   
  0.727
SAP18
SIN3 associated polypeptide P18; Links the histone deacetylase complex to transcriptional repressors bound to chromatin. Involved in the tethering of the SIN3 complex to core histone proteins (152 aa)
       
 
  0.692
HD1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral [...] (501 aa)
       
 
  0.659
PEP
PEPPER; Regulates vegetative and gynoecium development (PubMed-16356489). In concert with HUA2, antagonizes FLK by positively regulating FLC probably at transcriptional and post- transcriptional levels, and thus acts as a negative regulator of flowering (PubMed-19576878) (495 aa)
     
   
  0.637
AT2G39260
RNA binding protein; Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Required for plant development and adaptatio [...] (1181 aa)
           
  0.634
CID3
CTC-interacting domain 3 (587 aa)
           
  0.634
ETR1
ETHYLENE RESPONSE 1; Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling (PubMed-15466228, PubMed-15703053). In the presence of ethylene, the auto-kinase activity of ETR1 is inhibited and the non-phosphorylated kinase domain binds tightly to the corresponding domain of EIN2 (PubMed-20591837) (738 aa)
     
   
  0.625
TPL
TOPLESS; Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes (PubMed-23034631). Required for ovule development (PubMed-25378179) (1131 aa)
     
 
  0.613
TBL10
Uncharacterized protein; May be involved in the specific O-acetylation of cell wall polymers (469 aa)
           
  0.606
T21F11.18
TOPLESS-related 1; Transcriptional corepressor. Activates TIR-NB-LRR R protein-mediated immune responses through repression of negative regulators such as CNGC2/DND1 (PubMed-20647385). Negative regulator of jasmonate responses (By similarity) (1120 aa)
     
 
  0.567
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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