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SDG16 SDG16 SDG29 SDG29 AT3G21060 AT3G21060 SDG25 SDG25 AT5G14530 AT5G14530 AT5G66240 AT5G66240 SET27 SET27 TRO TRO SDG14 SDG14 SDG2 SDG2 WDR5a WDR5a
"TRO" - TRAUCO in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TROTRAUCO; Trithorax-group gene homolog required for early embryogenesis (PubMed-20118203, PubMed-21423667). Required for the expression of FLC and FLC homologs and represses flowering (PubMed-21423667). Required for proper leaf growth and development (PubMed-21423667). Part of COMPASS-like complexes responsible for H3K4 trimethylation, but not for di- or mono-methylation of histone H3 ’Lys-4’ (PubMed-21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed-21423667) (509 aa)    
Predicted Functional Partners:
AT3G21060
RbBP5 LIKE; Promotes the expression of FLC and FLC homologs to repress the floral transition (547 aa)
     
  0.998
WDR5a
WD40 domain-containing protein; Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 ’Lys- 4’ methyltransferases such as ATX1, SDG14 or SDG16 (PubMed-21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed-19567704). Upregulates FLC and MAF4 expression to delay flowering (PubMed-19567704) (317 aa)
     
  0.992
SET27
Homologue of trithorax; Histone methyltransferase. Methylates ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. Required to maintain the active state of class A (AP1 and AP2), class B (PI and AP3) and class C (AG) floral homeotic genes at early stages of flower development. Regulates floral organ identity and flowering transition. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity (1062 aa)
     
 
  0.968
SDG2
SET domain protein 2; Histone methyltransferase specifically required for trimethylation of ’Lys-4’ of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development (PubMed-21037105, PubMed-20937886) (2335 aa)
     
 
  0.968
AT5G66240
transducin/WD40 domain-containing protein (331 aa)
       
 
  0.968
AT5G14530
transducin/WD40 domain-containing protein (330 aa)
       
 
  0.968
SDG16
SET domain protein 16; Histone methyltransferase (1027 aa)
     
 
  0.968
SDG14
SET domain protein 14; Histone methyltransferase (1018 aa)
     
 
  0.966
SDG25
SET domain protein 25; Histone methyltransferase involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family (PubMed-19726574, PubMed-19855050). Required for histone H3 dimethylation on ’Lys-36’ H3K36me2 at the FLC locus (PubMed-19726574). Required for histone H3 trimethylation on ’Lys- 4’ H3K4me3 at the FLC locus. Prevents trimethylation on ’Lys-27’ H3K276me3 at the same locus (PubMed-19855050). Involved in the control of seed dormancy and germination (PubMed-21799800) (1423 aa)
     
 
  0.966
SDG29
SET domain group 29; Histone methyltransferase (1043 aa)
     
 
  0.963
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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