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AT5G55220 AT5G55220 MMH-1 MMH-1 AT4G12740 AT4G12740 AT3G52050 AT3G52050 AT4G32700 AT4G32700 AT5G26680 AT5G26680 AT3G48900 AT3G48900 POLGAMMA2 POLGAMMA2 AT1G29630 AT1G29630 POLGAMMA1 POLGAMMA1 UVH3 UVH3
"MMH-1" - MUTM homolog-1 in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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MMH-1MUTM homolog-1; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Can process efficiently 4,6- diamino-5-formamidopyrimidine (FapyA), 2,6-diamino-4- hydroxy-5- formamidopyrimidine (FapyG) and the further oxidation products of 8-oxoguanine (8-oxoG), such as guanidinohydantoin and spiroiminodihydantoin. Has marginal activity towards 8-oxoG. Has AP (apurinic/apyrimidinic) lyase activity. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of th [...] (390 aa)    
Predicted Functional Partners:
AT4G12740
A/G-specific adenine glycosylase; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities (By similarity) (630 aa)
   
 
  0.753
UVH3
DNA repair protein UVH3; Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3’-incision step in NER. Seems to play a role in senescence program (1479 aa)
   
   
  0.745
AT5G26680
Flap endonuclease-1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (453 aa)
   
   
  0.739
AT4G32700
DNA polymerase theta subunit; Required for regulated cell division and differentiation in meristems and embryos, thus modulating adaxial-abaxial polarity. Regulates the progression of cell cycle and DNA replication (e.g. G2/M progression and intrachromosomal recombination) and the expression of genes during development, especially genes nearby the Helitron transposons (2154 aa)
   
 
  0.724
AT3G48900
Flap endonuclease GEN-like 2 (600 aa)
   
   
  0.683
AT1G29630
Exonuclease 1; Putative 5’->3’ double-stranded DNA exonuclease which may also contain a cryptic 3’->5’ double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity) (735 aa)
   
   
  0.663
POLGAMMA1
Polymerase gamma 1; In addition to polymerase activity, this DNA polymerase 5’ to 3’ exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria (1049 aa)
   
   
  0.660
POLGAMMA2
Polymerase gamma 2; In addition to polymerase activity, this DNA polymerase 5’ to 3’ exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria. May be required for DNA repair in both organelles (1050 aa)
   
   
  0.654
AT5G55220
Trigger factor type chaperone family protein; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity) (547 aa)
       
 
  0.638
AT3G52050
5’-3’ exonuclease-like protein (448 aa)
   
   
  0.634
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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