Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
MTO 1 RESPONDING DOWN 1 (193 aa)
Predicted Functional Partners:
MTO 1 RESPONDING UP 1 (58 aa)
RING/U-box domain-containing protein; Ubiquitin E3 ligase required for class I crossing-over (CO) formation during meiosis (304 aa)
Expressed protein (466 aa)
Cystathionine gamma-synthase; Catalyzes the first committed step of methionine (Met) biosynthesis. Catalyzes the formation of L-cystathionine from homoserine esters and L-cysteine, via a gamma-replacement reaction. Substrate preference for cystathionine synthesis is O- phospho-L-homoserine (OPH) > O(4)-succinyl-L-homoserine (OSH) >> O-acetyl-L-homoserine (OAH). Is able, at extremely low rate, to catalyze a gamma-elimination of OPH in the absence of cysteine to produce inorganic phosphate (Pi), 2-oxobutanoate and ammonia (563 aa)
Uncharacterized protein (758 aa)
Cysteine/Histidine-rich C1 domain family protein (413 aa)
GILT domain-containing protein (265 aa)
Uncharacterized protein (656 aa)
Putative pathogenesis-related protein (186 aa)
FAD/NAD(P)-binding oxidoreductase family protein (477 aa)
Your Current Organism:
NCBI taxonomy Id: 3702 Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress