Full Link:
STRINGSTRING
AT5G03090 AT5G03090 AT3G27130 AT3G27130 MRD1 MRD1 HEI10 HEI10 AT3G27120 AT3G27120 SHOC1 SHOC1 ASY3 ASY3 MLH1 MLH1 ASY1 ASY1 MSH4 MSH4 MSH5 MSH5
"HEI10" - RING/U-box domain-containing protein in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HEI10RING/U-box domain-containing protein; Ubiquitin E3 ligase required for class I crossing-over (CO) formation during meiosis (304 aa)    
Predicted Functional Partners:
SHOC1
SHORTAGE IN CHIASMATA 1 (1594 aa)
           
  0.813
AT5G03090
Uncharacterized protein (97 aa)
     
   
  0.789
MRD1
MTO 1 RESPONDING DOWN 1 (193 aa)
     
   
  0.764
MSH4
MUTS-like protein 4; Involved in meiotic recombination in association with MSH5. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation (792 aa)
     
   
  0.754
AT3G27130
Uncharacterized protein (366 aa)
           
  0.738
AT3G27120
P-loop containing nucleoside triphosphate hydrolase-like protein (476 aa)
           
  0.738
ASY3
ASYNAPTIC 3 (793 aa)
           
  0.674
MSH5
MUTS-homologue 5; Involved in meiotic recombination in association with MSH4. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation (807 aa)
     
   
  0.660
MLH1
MUTL-homologue 1; Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in mai [...] (737 aa)
     
   
  0.636
ASY1
ASYNAPTIC 1 (596 aa)
     
   
  0.621
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (1%)