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eIFiso4G1 eIFiso4G1 eIFiso4G2 eIFiso4G2 AT4G30680 AT4G30680 EIF4G EIF4G MAGO MAGO AT1G62410 AT1G62410 EIF4A-2 EIF4A-2 Y14 Y14 UPF3 UPF3 AT3G26560 AT3G26560 AT1G80930 AT1G80930
"EIF4A-2" - Eif4a-2 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
EIF4A-2Eif4a-2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity) (412 aa)    
Predicted Functional Partners:
eIFiso4G1
MIF4G domain and MA3 domain-containing protein; Plays a role in the accumulation of some potyvirus during viral infection (780 aa)
     
  0.990
AT3G26560
ATP-dependent RNA helicase, putative; May be involved in pre-mRNA splicing (1168 aa)
   
 
  0.972
MAGO
MAGO NASHI (150 aa)
     
 
  0.967
Y14
RNA-binding protein 8A (202 aa)
     
 
  0.950
AT4G30680
Initiation factor eIF-4 gamma, MA3 (263 aa)
     
  0.941
AT1G62410
MIF4G domain-containing protein (223 aa)
     
  0.941
EIF4G
Translation initiation factor eIF-4F; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Plays a role in the accumulation of some potyvirus during viral infection. Required for the accumulation of cucumber mosaic virus 3a protein and turnip crinkle virus p28 replication protein during viral infection. These proteins are necessary for cell-to-cell movement of the virus (1727 aa)
     
  0.938
UPF3
Smg-4/UPF3-like protein; Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (premature termination codon PTC) by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Eliminates the production of nons [...] (484 aa)
       
 
  0.937
eIFiso4G2
MIF4G and MA3 domain-containing protein; Plays a role in the accumulation of some potyvirus during viral infection (747 aa)
     
 
  0.884
AT1G80930
pre-mRNA-splicing factor CWC22 (900 aa)
     
 
  0.879
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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