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FIB1 FIB1 AT3G05060 AT3G05060 AT5G27140 AT5G27140 AT5G27120 AT5G27120 AT5G52490 AT5G52490 AT3G09720 AT3G09720 XRN4 XRN4 DCP2 DCP2 FIB2 FIB2 DCP1 DCP1 AT4G17620 AT4G17620
"XRN4" - Exoribonuclease 4 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
XRN4Exoribonuclease 4; Possesses 5’->3’ exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA target cleavage products that lack a 5’-cap structure. Antagonizes the negative feedback regulation on EIN3 by promoting EBF1 and EBF2 mRNA decay, which consequently allows the accumulation of EIN3 protein to trigger the ethylene response (947 aa)    
Predicted Functional Partners:
DCP1
Decapping 1; As a component of the decapping complex, involved in the degradation of mRNAs. Essential for postembryonic development (367 aa)
     
 
  0.987
DCP2
Decapping 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Essential for postembryonic development, especially during the formation of the shoot apical meristem (SAM) (386 aa)
     
 
  0.980
AT4G17620
Glycine-rich protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5’ end cap and is part of a pre-mRNA capping quality control (544 aa)
     
 
  0.978
AT5G52490
Fibrillarin family protein; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L- methionine to catalyze the site-specific 2’-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of ’Gln-105’ of hi [...] (292 aa)
     
  0.959
FIB1
Fibrillarin 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and the general transcription factors (By similarity) (308 aa)
     
  0.959
FIB2
Fibrillarin 2; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and the general transcription factors (320 aa)
     
  0.959
AT5G27140
NOP56-like pre RNA processing ribonucleoprotein; Required for 60S ribosomal subunit biogenesis (445 aa)
     
  0.954
AT5G27120
Putative nucleolar protein 5-1; Required for 60S ribosomal subunit biogenesis (533 aa)
     
  0.954
AT3G05060
Putative nucleolar protein 5-2; Required for 60S ribosomal subunit biogenesis (533 aa)
     
  0.954
AT3G09720
DEAD-box ATP-dependent RNA helicase 57 (541 aa)
     
  0.944
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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