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AT3G62470 AT3G62470 MBD7 MBD7 DML1 DML1 MBD6 MBD6 AT1G20870 AT1G20870 AT5G02480 AT5G02480 MET18 MET18 AT1G54840 AT1G54840 ROS4 ROS4 IDL1 IDL1 AT3G48425 AT3G48425
"AT1G54840" - HSP20-like chaperones superfamily protein in Arabidopsis thaliana
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AT1G54840HSP20-like chaperones superfamily protein; Prevents DNA hypermethylation and transcriptional silencing of transgenes and of some endogenous genes (PubMed-25002145, PubMed-24920332). May act as a molecular chaperone of IDM1, regulating its H3K18 acetylation activity (PubMed-25002145, PubMed-24920332) (349 aa)    
Predicted Functional Partners:
MBD7
methyl-CPG-binding domain 7; Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed-25684209). Requires high mCG density for binding (PubMed-25684209, PubMed-25593350). Recognizes preferentially mCGs located in transposable elements (PubMed-25684209, PubMed-25593350). [...] (306 aa)
     
 
  0.994
ROS4
REPRESSOR OF SILENCING 4; Histone H3 acetyltransferase that binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and catalyzes H3K18 and H3K23 acetylation (PubMed-22733760, PubMed-22700931). Prevents the transcriptional silencing of transgenes and of some endogenous genes (PubMed-22733760, PubMed-22700931). Requires the presence of IDM2 for efficient H3K18 acetylation, but not for H3K23 acetylation (PubMed-25002145) (1189 aa)
     
 
  0.988
IDL1
Protein IDA-LIKE 1; Involved in an ethylene-independent separation step of floral abscission. May act with RLK5 and HSL2 as ligand-receptor pairs (86 aa)
       
 
  0.906
DML1
Protein ROS1; Bifunctional DNA glycosylase/lyase, which excises 5- methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed-25240767). Generates 3’-phosphor- alpha,beta-unsaturated aldehyde (3’-PUA) as a primary 5-meC excision intermediate (PubMed-25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. [...] (1393 aa)
     
 
  0.841
AT5G02480
HSP20-like chaperone (508 aa)
           
  0.744
AT3G62470
Pentatricopeptide repeat-containing protein (599 aa)
           
  0.738
AT1G20870
HSP20-like chaperones superfamily protein; Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed-25684209) (463 aa)
     
 
0.736
MBD6
methyl-CPG-binding domain 6; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. May associate with histone deacetylase proteins (HDAC). Required for nucleolar dominance that consist in the silencing of rRNA genes inherited from one progenitor in genetic hybrids. Recruited to rRNA genes in a DRM2-dependent manner (225 aa)
       
 
  0.714
AT3G48425
DNAse I-like superfamily protein; Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting (PubMed-25569774). According to a report, displays also an in vitro 3’-phosphatase activity (PubMed-25569774). According to another report, has no in vitro 3’-phosphatase activity (PubMed-25228464). Catalyzes the conversion of the 3’-blocking groups 3’-phosphor-alpha,beta- unsaturated aldehyde (3’-PUA) generated by ROS1 to 3’-OH (PubMed-25228464, PubMed-25569774). Has a strong non-specific affinity to DNA (PubMed-25228464). Redundant with APE2 and at least [...] (364 aa)
     
   
  0.696
MET18
Homolog of yeast MET18; May select specific target apoproteins to which a Fe-S cluster produced by the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) pathway is transferred (1134 aa)
           
  0.679
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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