Full Link:
STRINGSTRING
AHG2 AHG2 RRP45a RRP45a RRP41L RRP41L AT4G10070 AT4G10070 CER7 CER7 DCP2 DCP2 AT1G33680 AT1G33680 RRP4 RRP4 AT2G25970 AT2G25970 AT3G07750 AT3G07750 EMB2763 EMB2763
"AHG2" - ABA-HYPERSENSITIVE GERMINATION 2 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHG2ABA-HYPERSENSITIVE GERMINATION 2; 3’-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. Essential for early development, possibly by participating in silencing certain maternal mRNAs translationally. May have a pivotal role in stress response (689 aa)    
Predicted Functional Partners:
DCP2
Decapping 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Essential for postembryonic development, especially during the formation of the shoot apical meristem (SAM) (386 aa)
         
  0.943
EMB2763
EMBRYO DEFECTIVE 2763; Catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Required for 5.8S rRNA intermediate processing and the degradation of 5’ external transcribed spacer (5’ ETS), a maturation by-product of rRNA synthesis. Is not involved in the degradation of turnip crinkle virus (TCV) RNA and significant virus resistance (PubMed-24244451). Required for normal development of female gametophytes and early embryogenesis (PubMed-20798041, PubMed-24244451) (1012 aa)
     
 
  0.937
RRP45a
Ribonuclease PH45A; Probable 3’->5’ exoribonuclease involved in the regulation of cuticular wax biosynthesis. Can perform exosomal functions and partially complement the yeast rrp45 null mutant (307 aa)
     
 
  0.935
CER7
ECERIFERUM 7; Probable 3’->5’ exoribonuclease involved in the regulation of cuticular wax biosynthesis by controlling the expression of CER3. May act by degrading a specific mRNA species encoding a negative regulator of CER3 transcription. Can perform exosomal functions and complement the yeast rrp45 null mutant (438 aa)
     
 
  0.920
AT1G33680
KH domain-containing protein (763 aa)
     
  0.918
RRP4
Ribosomal RNA processing 4; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is an active and distributive 3’->5’ exonuclease requiring a free 3’-OH on the substrate and releasing nucleoside 5’-monophosphates (PubMed-11809881). Required for normal embryo development (PubMed-18160042) (322 aa)
     
 
  0.916
AT2G25970
KH domain-containing protein (632 aa)
     
  0.913
RRP41L
RRP41 like; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is a processive phosphorolytic exonuclease and requires a single-stranded poly(A) tail on the substrate RNA for its activity (By similarity). Plays an important role in seed germination and early seedling growth by mediating specific cytoplasmic mRNA decay of transcripts coding for the abscisic acid (ABA) biosynthetic enzymes NCED5 and NCED6, and the ABA signaling transcription f [...] (256 aa)
     
 
  0.911
AT3G07750
3’-5’-exoribonuclease family protein (286 aa)
     
 
    0.910
AT4G10070
KH domain-containing protein (725 aa)
     
  0.910
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (1%)