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RPA70D RPA70D CUL4 CUL4 RPA70B RPA70B NRPB1 NRPB1 AT1G49250 AT1G49250 HAC4 HAC4 CHR8 CHR8 HAC2 HAC2 HSFA9 HSFA9 HSFB2A HSFB2A HSF1 HSF1
"HAC4" - Histone acetyltransferase of the CBP family 4 in Arabidopsis thaliana
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HAC4Histone acetyltransferase of the CBP family 4; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (1456 aa)    
Predicted Functional Partners:
RPA70D
Replication factor-A protein 1-related; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity) (629 aa)
       
    0.941
RPA70B
RPA70-kDa subunit B; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity). Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity) (604 aa)
       
    0.941
CHR8
Chromatin remodeling 8; Essential factor involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II- blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation (1187 aa)
     
  0.939
NRPB1
RNA polymerase II large subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. NRPB1 is part of the core element with the central large cleft, the cl [...] (1839 aa)
     
  0.937
CUL4
Cullin4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4- DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitin [...] (792 aa)
     
    0.925
HAC2
E1A/CREB-binding protein; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). No acetyltransferase activity found in vitro (1367 aa)
     
 
0.920
AT1G49250
ATP-dependent DNA ligase (657 aa)
     
 
  0.918
HSF1
Heat shock factor 1; Transcriptional activator that specifically binds DNA sequence 5’-AGAAnnTTCT-3’ known as heat shock promoter elements (HSE) (495 aa)
     
    0.914
HSFB2A
Heat shock transcription factor B2A; Transcriptional regulator that specifically binds DNA sequence 5’-AGAAnnTTCT-3’ known as heat shock promoter elements (HSE) (299 aa)
     
    0.911
HSFA9
Heat shock transcription factor A9; Seed-specific transcriptional regulator that specifically binds DNA sequence 5’-AGAAnnTTCT-3’ known as heat shock promoter elements (HSE). Seems to be specialized for the developmental expression of heat shock protein (HSP) genes during seed maturation. Activated by ABI3 (331 aa)
     
    0.911
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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