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AT4G17245 AT4G17245 AtPOT1a AtPOT1a AtPOT1b AtPOT1b CTC1 CTC1 TERT TERT MDO1 MDO1 STN1 STN1 AT1G09935 AT1G09935 AT1G09932 AT1G09932 AT1G09470 AT1G09470 ZW2 ZW2
"MDO1" - Uncharacterized protein in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MDO1Uncharacterized protein; Required for the maintenance of meristems and stem cells through the reduction of DNA damage (PubMed-21781195). Promotes telomere integrity by maintaining telomere length and proper architecture of the chromosome terminus (PubMed-23572541). Negatively regulates telomerase repeat addition processivity (PubMed-23572541). Hampers contacts between enzymatically active telomerase and CST complex (PubMed-25329641) (127 aa)    
Predicted Functional Partners:
STN1
CST complex subunit STN1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves (PubMed-19064932). Associates with enzymatically active telomerase (PubMed-25329641). Plays a genomewide role in DNA replication and facilitates re- replication at non-telomeric loci (PubMed-25299252) (160 aa)
           
  0.983
CTC1
CST complex subunit CTC1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves (PubMed-19854131). Associates with enzymatically active telomerase (PubMed-25329641) (1274 aa)
           
  0.960
AtPOT1a
Protection of Telomeres 1a; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for positive telomere length regulation. Binds specifically the telomerase RNA template component TER1. Does not bind single-stranded telomeric DNA. Not required to recruit telomerase to telomeres, but stimulates TER1 RNP repeat addition processivity (PubMed-25329641) (467 aa)
           
  0.849
AtPOT1b
Protection of telomeres 1b; Negatively regulates telomerase activity and participate in telomere end-protection. Does not bind single-stranded telomeric DNA (454 aa)
           
  0.842
TERT
Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Required to prevent genome instability induced by breakage-fusion-bridge (BFB) cycles. Can extend completely non-telomeric sequences using RNA template in vitro (1123 aa)
           
  0.676
AT1G09470
Uncharacterized protein (336 aa)
           
  0.675
AT1G09935
Phosphoglycerate mutase-like protein (231 aa)
           
  0.674
AT1G09932
Phosphoglycerate mutase family protein (260 aa)
           
  0.674
ZW2
Transcription factor-related (225 aa)
           
  0.633
AT4G17245
RING/U-box superfamily protein (166 aa)
           
  0.609
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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