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bHLH39 bHLH39 NRAMP4 NRAMP4 BHLH101 BHLH101 FRO3 FRO3 IREG2 IREG2 OPT3 OPT3 BHLH100 BHLH100 NAS4 NAS4 PYE PYE FRO2 FRO2 NRAMP3 NRAMP3
"NAS4" - Nicotianamine synthase in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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NAS4Nicotianamine synthase; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron (324 aa)    
Predicted Functional Partners:
NRAMP4
Metal transporter Nramp4; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP3 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP3, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts (512 aa)
           
  0.828
FRO2
Ferric reduction oxidase 2; Flavocytochrome that transfers electrons across the plasma membrane to reduce ferric iron chelates to form soluble ferrous iron in the rhizosphere. May be involved in the delivery of iron to developing pollen grains. Acts also as a copper-chelate reductase. Involved in glycine betaine-mediated chilling tolerance and reactive oxygen species accumulation (725 aa)
           
  0.812
PYE
POPEYE (240 aa)
           
  0.809
FRO3
Ferric reduction oxidase 3; Ferric chelate reductase involved in iron reduction in roots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates (717 aa)
           
  0.806
IREG2
Iron regulated 2; Vacuolar transporter that is involved in the transport of excess nickel into the vacuole under iron deficiency, increasing cellular tolerance to nickel under iron deficiency stress response (512 aa)
           
  0.802
BHLH101
Transcription factor bHLH101 (240 aa)
           
  0.801
NRAMP3
Metal transporter Nramp3; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP4 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP4, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts. Involved in basal resistance to the bacterial pathogen E.chrysanthemi (509 aa)
           
  0.762
OPT3
Oligopeptide transporter; May be involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner. Acts also as a metal transporter that could be a component of the copper transport machinery. Essential for early embryo development (737 aa)
     
   
  0.755
BHLH100
Transcription factor bHLH100; Plays a role in metal homeostasis. Confers tolerance to high zinc (Zn) and nickel (Ni) (242 aa)
     
   
  0.752
bHLH39
Basic helix-loop-helix 39 (258 aa)
     
   
  0.746
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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