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GUN5 GUN5 GUN4 GUN4 ERS ERS GSA1 GSA1 AT5G26710 AT5G26710 GSA2 GSA2 HEMA1 HEMA1 hemb2 hemb2 HEMB1 HEMB1 FLU FLU PGR7 PGR7
"HEMA1" - glutamyl-tRNA reductase 1 in Arabidopsis thaliana
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Predicted Interactions
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protein homology
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HEMA1glutamyl-tRNA reductase 1; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA). Probably involved in the tetrapyrrole synthesis required for the chlorophyll biosynthesis (543 aa)    
Predicted Functional Partners:
GSA2
Glutamate-1-semialdehyde 2,1-aminomutase 2; Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles (By similarity) (472 aa)
 
  0.999
GSA1
Glutamate-1-semialdehyde-2,1-aminomutase; Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles (474 aa)
 
  0.999
GUN5
GENOMES UNCOUPLED 5; Multifunctional protein involved in chlorophyll synthesis, plastid-to-nucleus retrograde signaling and abscisic acid (ABA) perception. In chlorophyll synthesis, catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX. The reaction takes place in two steps, with an ATP-dependent activation followed by an ATP-dependent chelation step. In addition to its function in the Mg-chelatase enzyme, is required for the plastid-to-nucleus retrogade signaling. The plastid-to-nucleus signal plays an important role in the coordinated expressi [...] (1381 aa)
     
   
  0.968
ERS
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (570 aa)
     
 
  0.967
PGR7
Proton gradient regulation 7; Involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis (PubMed-22180625). Stimulates GluTR activity and regulates glutamate-1-semialdehyde release. May play a role in heme metabolism (PubMed-24753615). Necessary for efficient photosynthetic electron transport in chloroplasts (PubMed-20657737) (317 aa)
       
 
  0.966
AT5G26710
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (719 aa)
         
  0.964
FLU
FLUORESCENT IN BLUE LIGHT; Negative regulator of tetrapyrrole biosynthesis (including chlorophyll) in chloroplasts, probably via HEMA1 repression. Inhibits especially the magnesium ion Mg(2+) branch of tetrapyrrole biosynthesis, but independently of heme (317 aa)
     
 
  0.959
hemb2
Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity) (406 aa)
 
 
  0.945
HEMB1
Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity) (430 aa)
 
 
  0.941
GUN4
GENOMES UNCOUPLED 4; Regulates chlorophyll synthesis and plastid-to-nucleus signal transduction by binding both the product and the substrate of Mg-chelatase, an enzyme that produces magnesium-protoporphyrin IX (Mg-Proto). Activates also Mg-chelatase. Neither binds abscisic acid (ABA) nor is involved in ABA signaling (265 aa)
     
   
  0.932
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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