Full Link:
STRINGSTRING
PIS2 PIS2 PIS1 PIS1 PGPS2 PGPS2 PGP1 PGP1 CDS1 CDS1 CLS CLS ATS2 ATS2 LPAT5 LPAT5 LPAT2 LPAT2 LPAT3 LPAT3 LPAT4 LPAT4
"CDS1" - CDP-diacylglycerol synthase 1 in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDS1CDP-diacylglycerol synthase 1; May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction (421 aa)    
Predicted Functional Partners:
PGP1
Phosphatidylglycerolphosphate synthase 1; Catalyzes the committed step to the synthesis of the acidic phospholipids. Transfers specifically a phosphatidyl group from CDP-diacylglycerol to glycerol-3-phosphate to form phosphatidylglycerophosphate. Cannot catalyze the phosphatidyl group transfer to inositol, serine, choline or phosphatidylglycerol. Possesses high activity with CDP- dipalmitoylglycerol and low activity with CDP-dioleoylglycerol (296 aa)
   
 
  0.990
CLS
Cardiolipin synthase; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). Cannot catalyze the phosphatidyl group transfer from one PG molecule to another to form CL. Possesses high activity with PG species carrying dioleoyl groups and low activity with species carrying one or two palmitoyl groups. CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and st [...] (341 aa)
   
 
  0.978
ATS2
1-acyl-sn-glycerol-3-phosphate acyltransferase 1; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C-16-CoA substrates compared to C-18-CoA substrates. Essential for embryo development during the transition from the globular to the heart stage when chloroplasts begin to form (356 aa)
   
 
  0.973
LPAT2
Lysophosphatidyl acyltransferase 2; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C-18-CoA substrates compared to C-16-CoA substrates. Required for female but not male gametophyte development (389 aa)
   
 
  0.973
LPAT5
Lysophosphatidyl acyltransferase 5; May convert lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position (By similarity). Has no activity when expressed in bacteria or yeast (375 aa)
   
 
  0.973
LPAT4
Lysophosphatidyl acyltransferase 4; May convert lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position (By similarity). Has no activity when expressed in bacteria or yeast (378 aa)
   
 
  0.973
LPAT3
Lysophosphatidyl acyltransferase 3; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C-18-CoA substrates compared to C-16-CoA substrates (376 aa)
   
 
  0.973
PIS2
Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity) (225 aa)
   
 
  0.972
PIS1
Phosphatidylinositol synthase 1; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (227 aa)
   
 
  0.972
PGPS2
Phosphatidylglycerolphosphate synthase 2; This protein catalyzes the committed step to the synthesis of the acidic phospholipids (233 aa)
   
 
  0.971
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (2%)