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MUS81 MUS81 ATR ATR RAD51 RAD51 XRCC3 XRCC3 MRE11 MRE11 SPO11-2 SPO11-2 ASY1 ASY1 RAD50 RAD50 TOP6B TOP6B DMC1 DMC1 RAD51C RAD51C
"SPO11-2" - Sporulation 11-2 in Arabidopsis thaliana
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SPO11-2Sporulation 11-2; Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed-17018031, PubMed-17965269, PubMed-26917763). Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed-26917763). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed-17018031, PubMed-17965269, PubMed-26917763) (383 aa)    
Predicted Functional Partners:
TOP6B
Topoisomerase 6 subunit B; Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. Involved in cell-elongation processes (670 aa)
 
 
 
  0.995
RAD50
DNA repair protein RAD50; Implicated in double-strand breaks (DSBs) repair by non- homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division (1316 aa)
     
 
  0.979
DMC1
DISRUPTION OF MEIOTIC CONTROL 1; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (344 aa)
     
 
  0.974
RAD51
DNA repair protein RAD51-like 1; Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis (342 aa)
     
 
  0.974
ATR
Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis proce [...] (2702 aa)
       
 
  0.967
MUS81
MMS AND UV SENSITIVE 81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5’-end at the branch nick. Typical substrates include 3’- flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombinati [...] (659 aa)
     
 
  0.948
ASY1
ASYNAPTIC 1 (596 aa)
     
   
  0.945
MRE11
MEIOTIC RECOMBINATION 11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand- specific 3’-5’ exonuclease activity. Also involved in meiotic DSB processing (By similarity) (720 aa)
     
 
  0.944
RAD51C
DNA repair protein RAD51-like 3 (387 aa)
     
 
  0.938
XRCC3
DNA repair protein XRCC3-like protein; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross- links repair and is involved in double strand breaks (DSBs) repair (304 aa)
     
 
  0.930
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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