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RBR1 RBR1 AT4G15890 AT4G15890 HEB1 HEB1 HEB2 HEB2 SMC3 SMC3 MCM3 MCM3 SMC2 SMC2 ATSMC2 ATSMC2 EMB2656 EMB2656 MCM5 MCM5 AT3G57060 AT3G57060
"HEB1" - ARM repeat superfamily protein in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
HEB1ARM repeat superfamily protein (1203 aa)    
Predicted Functional Partners:
HEB2
Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). The condensin-2 complex plays a role in DNA damage repair or in protecting the genome from certain genotoxic stressors (e.g. boron excess, zeocin and aphidicolin) (683 aa)
     
  0.999
AT4G15890
Binding (1314 aa)
     
  0.998
SMC3
Member of SMC subfamily; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis (1244 aa)
     
  0.980
RBR1
Retinoblastoma-related 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate (PubMed-18064404, PubMed-21444209). Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation (PubMed-22307083). Plays a central role in the mechanism controlling meristem cell differentia [...] (1013 aa)
     
 
    0.960
ATSMC2
Member of SMC subfamily; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis (1171 aa)
     
  0.958
SMC2
SMC2-1 (SMC2); Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis (1175 aa)
     
  0.955
EMB2656
EMBRYO DEFECTIVE 2656 (1051 aa)
     
   
  0.948
MCM3
MINICHROMOSOME MAINTENANCE 3; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells (776 aa)
     
   
  0.942
AT3G57060
Binding; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (1415 aa)
     
   
  0.886
MCM5
MINICHROMOSOME MAINTENANCE 5; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells (727 aa)
     
   
  0.799
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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