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AT1G66500 AT1G66500 AT5G43620 AT5G43620 AT4G25550 AT4G25550 CFIM-25 CFIM-25 FIP1[V] FIP1[V] CPSF30 CPSF30 CPSF100 CPSF100 CSTF77 CSTF77 PCFS4 PCFS4 AT3G66652 AT3G66652 CLPS3 CLPS3
"AT1G66500" - Pre-mRNA cleavage complex II in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
AT1G66500Pre-mRNA cleavage complex II (416 aa)    
Predicted Functional Partners:
CSTF77
Tetratricopeptide repeat-containing protein; One of the multiple factors required for polyadenylation and 3’-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3’ processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (PubMed-19965720) (734 aa)
     
  0.999
AT3G66652
Fip1 motif-containing protein; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (997 aa)
     
  0.999
CLPS3
CLP-like protein 3; Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3’-end formation (By similarity). Functions in gametophyte, embryo and postembryotic development (PubMed-18971429) (444 aa)
       
  0.999
AT5G43620
Pre-mRNA cleavage complex II (410 aa)
     
0.999
PCFS4
PCF11P-similar protein 4; Promotes flowering by suppressing FLC-mediated inhibition of flowering through the regulation of FCA pre-mRNA alternative processing (PubMed-18298670). Regulates mRNA maturation including alternative polyadenylation, splicing or transcription initiation of stress-associated genes (PubMed-21364912) (808 aa)
       
0.999
CPSF30
Cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection (PubMed-23136375). Binds RNA in a calcium-dependent manner (PubMed-16500995, PubMed-17576667, PubMed-20214900). Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3’ ends with hydro [...] (631 aa)
     
  0.999
FIP1[V]
FIP1 [V]-like protein; Essential gene (PubMed-16282318). Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity) (1196 aa)
       
  0.991
CFIM-25
Homolog of CFIM-25; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export (222 aa)
       
  0.986
AT4G25550
Cleavage/polyadenylation specificity factor; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3’-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3’-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5’-UGUA-3’ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export (200 aa)
       
  0.985
CPSF100
Cleavage and polyadenylation specificity factor 100; CPSF plays a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Required for antisense-RNA- mediated gene silencing (PubMed-17008405) (739 aa)
     
  0.984
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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