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SPO11-2 SPO11-2 MLH3 MLH3 MSH4 MSH4 ATMND1 ATMND1 MLH1 MLH1 Hop1 Hop1 ASY1 ASY1 DMC1 DMC1 ATSPO11-1 ATSPO11-1 RAD51 RAD51 ASY3 ASY3
"ASY1" - ASYNAPTIC 1 in Arabidopsis thaliana
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ASY1ASYNAPTIC 1 (596 aa)    
Predicted Functional Partners:
DMC1
DISRUPTION OF MEIOTIC CONTROL 1; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (344 aa)
     
 
  0.987
ASY3
ASYNAPTIC 3 (793 aa)
       
 
  0.978
ATSPO11-1
Meiotic recombination protein SPO11-1; Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed-11157765, PubMed-17018031, PubMed-17965269, PubMed-26917763). Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed-26917763). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed-11157765, PubMed-17018031, PubMed-17965269, PubMed-26917763) (362 aa)
     
   
  0.975
RAD51
DNA repair protein RAD51-like 1; Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis (342 aa)
     
 
  0.964
ATMND1
Meiotic nuclear division protein 1-like protein; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1/LIM15- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (230 aa)
       
 
  0.962
Hop1
Hop1; Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity) (572 aa)
     
   
  0.960
MSH4
MUTS-like protein 4; Involved in meiotic recombination in association with MSH5. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation (792 aa)
     
   
  0.958
SPO11-2
Sporulation 11-2; Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed-17018031, PubMed-17965269, PubMed-26917763). Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed-26917763). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed-17018031, PubMed-17965269, PubMed-26917763) (383 aa)
     
   
  0.945
MLH1
MUTL-homologue 1; Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in mai [...] (737 aa)
           
  0.924
MLH3
MUTL protein homolog 3; Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved [...] (1169 aa)
           
  0.922
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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