Full Link:
STRINGSTRING
HAI1 HAI1 SAG13 SAG13 NAC6 NAC6 SAG12 SAG12 GRL GRL NAP NAP NYE1 NYE1 G18F G18F AP3 AP3 PI PI IAA14 IAA14
"NAP" - NAC-like, activated by AP3/PI in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NAPNAC-like, activated by AP3/PI; Transcription factor of the NAC family involved in senescence. May function in the transition between active cell division and cell expansion (268 aa)    
Predicted Functional Partners:
NAC6
NAC domain containing protein 6; Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5’- [ACG][CA]GT[AG](5-6n)[CT]AC[AG]-3’ (PubMed-23340744). Promotes lateral root development (PubMed-16359384). Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with salt- and H(2)O(2)-dependent signaling pathways (PubMed-9351240, PubMed-15295076, PubMed-20113437, PubMed-21303842). Regulates also genes during seed germination (PubMed-20113437). Re [...] (285 aa)
     
 
0.887
HAI1
Protein phosphatase (413 aa)
     
   
  0.710
SAG12
Senescence-associated gene 12; Cysteine protease that may have a developmental senescence specific cell death function during apoptosis, heavy metal detoxification, and hypersensitive response (346 aa)
           
  0.670
PI
PISTILLATA; Probable transcription factor involved in the genetic control of flower development. Is required for normal development of petals and stamens in the wild-type flower. Forms a heterodimer with APETALA3 that is required for autoregulation of both AP3 and PI genes. AP3/PI heterodimer interacts with APETALA1 or SEPALLATA3 to form a ternary complex that could be responsible for the regulation of the genes involved in the flower development. AP3/PI heterodimer activates the expression of NAP (208 aa)
           
  0.634
GRL
GNARLED; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (1425 aa)
       
 
  0.583
IAA14
Auxin-responsive protein IAA14; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression (228 aa)
       
      0.561
AP3
APETALA 3; Probable transcription factor involved in the genetic control of flower development. Is required for normal development of petals and stamens in the wild-type flower. Forms a heterodimer with PISTILLATA that is required for autoregulation of both AP3 and PI genes. AP3/PI heterodimer interacts with APETALA1 or SEPALLATA3 to form a ternary complex that could be responsible for the regulation of the genes involved in the flower development. AP3/PI heterodimer activates the expression of NAP (232 aa)
           
  0.560
G18F
Autophagy 18F-like protein; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy (By similarity) (763 aa)
     
   
  0.547
NYE1
NON-YELLOWING 1; Involved in the disassembling mechanism of the intact light-harvesting complex of photosystem II (LHCII) in the thylakoid membranes. Required to trigger chlorophyll degradation during natural and dark-induced leaf senescence. Regulated at the transcriptional level by ABI3 (268 aa)
     
   
  0.537
SAG13
Senescence-associated gene 13; Unspecific reductase providing both diastereomeric alcohols from the prochiral ketones. Active on cyclic monoterpenes and small flexible lipophilic carbonyls. No activity with tropinone, nitrogen-containing tropinone analogs, tropine or pseudotropine as substrate (269 aa)
     
   
  0.535
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (1%)