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PGSC0003DMT400029859 PGSC0003DMT400029859 PGSC0003DMT400073770 PGSC0003DMT400073770 PGSC0003DMT400068136 PGSC0003DMT400068136 PGSC0003DMT400074009 PGSC0003DMT400074009 PGSC0003DMT400074197 PGSC0003DMT400074197 PGSC0003DMT400000377 PGSC0003DMT400000377 CNX5 CNX5 PGSC0003DMT400050077 PGSC0003DMT400050077 PGSC0003DMT400060898 PGSC0003DMT400060898 PGSC0003DMT400012014 PGSC0003DMT400012014 PGSC0003DMT400068285 PGSC0003DMT400068285
"PGSC0003DMT400000377" - Conserved gene of unknown function in Solanum tuberosum
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PGSC0003DMT400000377Conserved gene of unknown function; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress spec [...] (99 aa)    
Predicted Functional Partners:
PGSC0003DMT400074009
Molybdopterin synthase sulphurylase (286 aa)
     
  0.989
CNX5
Molybdopterin synthase sulphurylase; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is gener [...] (460 aa)
     
  0.989
PGSC0003DMT400073770
Cysteine desulfurylase (660 aa)
       
  0.828
PGSC0003DMT400060898
Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position (481 aa)
       
  0.827
PGSC0003DMT400012014
Parvulin-type peptidyl prolyl cis/trans isomerase (236 aa)
     
 
  0.821
PGSC0003DMT400068285
Raspberry3 (639 aa)
       
  0.661
PGSC0003DMT400074197
Vacuolar H+-ATPase A1 subunit isoform (623 aa)
       
      0.638
PGSC0003DMT400068136
Vacuolar H+-ATPase A2 subunit isoform (623 aa)
       
      0.638
PGSC0003DMT400050077
Thioredoxin 1 (176 aa)
       
      0.638
PGSC0003DMT400029859
Thioredoxin 1 (552 aa)
       
      0.638
Your Current Organism:
Solanum tuberosum
NCBI taxonomy Id: 4113
Other names: S. tuberosum, Solanum tuberosum, Solanum tuberosum L., Solanum tuberosum subsp. tuberosum, potato, potatoes
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