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SCO0481 SCO0481 SCO0734 SCO0734 SCO1060 SCO1060 SCO1391 SCO1391 SCO1734 SCO1734 SCO1942 SCO1942 SCO2758 SCO2758 SCO2789 SCO2789 SCO2833 SCO2833 SCO2907 SCO2907 SCO4564 SCO4564 SCO4740 SCO4740 SCO4889 SCO4889 SCO5003 SCO5003 SCO5231 SCO5231 SCO5236 SCO5236 SCO5424 SCO5424 SCO5425 SCO5425 SCO5673 SCO5673 SCO5680 SCO5680 SCO5841 SCO5841 SCO6659 SCO6659 SCO7225 SCO7225
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO0481SCF80.02, possible secreted chitin binding protein, len: 172 aa. This CDS has been previously sequenced but was unclassified: Streptomyces coelicolor TR:Q9Z9M5 (EMBL; AB017013) gene for ChiG, partial CDS (fragment) (172 aa), fasta scores opt: 1151 z-score: 1339.7 E():0 99.4% identity in 172 aa overlap. This CDS is similar to several e.g. Streptomyces reticuli TR:O87962 (EMBL; Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 193 z-score: 234.7 E(): 1e-05 37.3% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (172 aa)
SCO07343SC5B7.12c, probable transcriptional repressor, len: 424 aa; similar to SW:MLC_ECOLI (EMBL:D32222) Escherichia coli transcriptional regulator Mlc protein, 406 aa; fasta scores: opt: 387 z-score: 414.7 E(): 1.4e-15; 24.1% identity in 344 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and possible helix-turn-helix motif at residues 64..85 (+6.19 SD). (424 aa)
SCO1060SCG22.06, probable transcriptional repressor, len: 413 aa; similar to TR:O05180 (EMBL:Z71474) Bacillus megaterium Xyl repressor XylR, 388 aa; fasta scores: opt: 382 z-score: 417.8 E(): 8.5e-16; 31.3% identity in 386 aa overlap and to TR:CAB61583 (EMBL:AL133210) Streptomyces coelicolor possible xylose repressor SCF37.02, 402 aa; fasta scores: opt: 586 z-score: 523.0 E(): 1.5e-23; 48.0% identity in 396 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and a possible helix-turn-helix motif at residues 35..56 (+3.03 SD). (413 aa)
SCO1391Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (556 aa)
SCO1734SCI11.23, possible secreted cellulose-binding protein, len: 356 aa; similar cellulose-binding proteins e.g. TR:O07862 (EMBL:U51222) Streptomyces halstedii cellulose-binding protein (364 aa), fasta scores; opt: 584 z-score: 557.4 E(): 1e-23, 35.7% identity in 305 aa overlap. Weaker similarity to chitin-binding proteins e.g. TR:O87962 (EMBL:Y14315) Streptomyces reticuli chitin-binding protein (201 aa) (32.7% identity in 214 aa overlap) secreted when co-cultivated with chitin-containing fungi. Weak similarity to TR:O86614 (EMBL:AL031155) S.coelicolor possible secreted chitinase (252 aa) ( [...] (356 aa)
SCO1942SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] (551 aa)
SCO2758SCC57A.29, nagA, beta-N-acetylglucosaminidase (putative secreted protein), len: 615 aa, Highly similar to Streptomyces thermoviolaceus TR:O82840 (EMBL:AB008771) beta-N-acetylglucosaminidase precursor (EC 3.2.1.30) (632 aa), fasta scores opt: 3169 z-score: 3414.1 E():0 80.0% identity in 614 aa overlap. Note the N-terminus of the S. coelicolor protein varies significantly from that of the S. thermoviolaceus protein. Contains a Prosite hit to PS00775 Glycosyl hydrolases family 3 active site and a Pfam match to entry PF00933 Glyco_hydro_3, Glycosyl hydrolase family 3. Also contains a possi [...] (615 aa)
SCO2789Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
SCO2833SCE20.07c, chb, secreted chitin binding protein, len: 201 aa. Highly similar to several including: Streptomyces olivaceoviridis (Streptomyces corchorusii) TR:Q54501(EMBL:X78535) chitin binding protein precursor Chb1 (201 aa), fasta scores opt: 1185 z-score: 1303.0 E():0 83.7% identity in 202 aa overlap and Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (Chb2) (201 aa), fasta scores opt: 1161 z-score: 1276.8 E(): 0 79.1% identity in 201 aa overlap. Contains a possible N-terminal signal sequence. (201 aa)
SCO2907Putative PTS transmembrane component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine (GlcNAc) transport. High-affinity permease, which exhibits a narrow specificity for GlcNAc. Essential for C-signaling between vegetative growth and development. (416 aa)
SCO4564NuoC, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (251 aa)
SCO4740Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (615 aa)
SCO48892SCK8.15, probable cytidine deaminase, len: 130 aa; similar to SW:CDD_HUMAN (EMBL:L27943) Homo sapiens cytidine deaminase (EC 3.5.4.5) Cda or Cdd, 146 aa; fasta scores: opt: 297 z-score: 380.0 E(): 1.3e-13; 36.2% identity in 130 aa overlap and to TR:53367 (EMBL:AL021841) Mycobacterium tuberculosis cytidine deaminase Cdd or MTV016.15c, 133 aa; fasta scores: opt: 518 z-score: 652.9 E(): 8.4e-29; 61.1% identity in 126 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region and match to Prosite entry PS00903 Cytidine and de [...] (130 aa)
SCO5003SCK15.05c, chiA, chinitase A precursor, len: 571 aa; identical to previously sequenced TR:Q9Z9M9 (EMBL:AB017008) Streptomyces coelicolor chinitase A precursor ChiA, 571 aa and to TR:Q59924 (EMBL:D13775) Streptomyces lividans chitinase A precursor (EC 3.2.1.14) ChiA, 571 aa. Contains Pfam match to entry PF02018 CBD_6, Cellulose binding domain, PF00041 fn3, Fibronectin type III domain, PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and matches to Prosite entries PS00678 Trp-Asp (WD) repeats signature and PS01095 Chitinases family 18 active site. Contains also possible N-terminal r [...] (571 aa)
SCO5231Putative gntR-family transcriptional regulator; Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N- acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Binds to the DNA consensus sequence 5'-ACTG [...] (254 aa)
SCO5236Putative glucosamine phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (261 aa)
SCO5424Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (407 aa)
SCO5425Phosphate acetyltransferase (fragment); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (697 aa)
SCO5673SC8B7.05c, chiB, secreted chitinase, len: 610 aa; almost identical to S. lividans TR:D1026067 (EMBL:D84193) chitinase ChiB (EC 3.2.1.14) (610 aa), 99.3% identity in 610 aa overlap, and highly similar to many e.g. CHIX_STROI Streptomyces olivaceoviridis exochitinase 1 precursor (EC 3.2.1.14) (597 aa), fasta scores; opt: 3484 z-score: 2485.6 E(): 0, 86.1% identity in 596 aa overlap. Contains PS01095 Chitinases family 18 active site. Contains possible N-terminal region signal peptide sequence. (610 aa)
SCO5680SC5H4.04c, probable cytidine deaminase, len: 137 aa; similar to TR:O53367 (EMBL:AL021841) Mycobacterium tuberculosis cytidine deaminase Cdd, 133 aa; fasta scores: opt 185 z-score: 244.6 E(): 3.6e-06; 37.4% identity in 115 aa overlap and to SW:CDD_MOUSE (EMBL:AA388666) Mus musculus cytidine deaminase (EC 3.5.4.5) Cdd, 146 aa; fasta scores: opt: 173 z-score: 229.1 E(): 2.6e-05; 29.2% identity in 113 aa overlap. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region and match to Prosite entry PS00903 Cytidine and deoxycytidylate deam [...] (137 aa)
SCO5841Phosphocarrier protein hpr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (93 aa)
SCO6659SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266. (550 aa)
SCO7225SC2H12.24, secreted chitinase, len: 244 aa. The N-terminal is highly similar to several chitin binding proteins e.g. Streptomyces reticuli TR:O87962(EMBL:Y14315) chitin binding protein (CHB2) (201 aa), fasta scores opt: 181 z-score: 193.2 E(): 0.0027 38.4% identity in 203 aa overlap. The C-terminal is similar to many chitinases e.g. Streptomyces olivaceoviridis TR:CAB83055(EMBL:AJ276990) chitinase precursor (EC 3.2.1.14) (781 aa), fasta scores opt: 322 z-score: 324.1 E(): 1.4e-10 36.5% identity in 167 aa overlap. Also highly similar to several Streptomyces coelicolor chitinases e.g. TR [...] (244 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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