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SCO1815 SCO1815 SCO3820 SCO3820 SCO3821 SCO3821 SCO3848 SCO3848 SCO4184 SCO4184 SCO4501 SCO4501 SCO4681 SCO4681 SCO4775 SCO4775 SCO4777 SCO4777 SCO5003 SCO5003 SCO5112 SCO5112 SCO5376 SCO5376 SCO5621 SCO5621 SCO5723 SCO5723 SCO5793 SCO5793 SCO6249 SCO6249 SCO6264 SCO6264 SCO7240 SCO7240 SCO7266 SCO7266 SCO1489 SCO1489 SCO3549 SCO3549 SCO3543 SCO3543 SCO3502 SCO3502 SCO2792 SCO2792 SCO2110 SCO2110 SCO1346 SCO1346 SCO0330 SCO0330 SCO1950 SCO1950 SCO1831 SCO1831
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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textmining
co-expression
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SCO1815Probable 3-oxacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (234 aa)
SCO3820SCGD3.21c, probable serine/threonine protein kinase, len: 522 aa; similar to many e.g. (EMBL:AF094711), PksC, Streptomyces coelicolor serine/threonine protein kinase (556 aa), fasta scores; opt: 907 z-score: 635.3 E(): 4.6e-28, 36.6% identity in 558 aa overlap, which lies upstream, on the opposite strand. Similar to mycobacterial putative serine/threonine protein kinases, but divergent at the C-terminal end e.g. TR:P71584 (EMBL:Z80233), PknB, Mycobacterium tuberculosis putative serine/threonine protein kinase (626 aa) (42.3% identity in 437 aa overlap). Contains a hydrophobic, possible [...] (522 aa)
SCO3821SCGD3.22, pksC, serine/threonine protein kinase, len: 556 aa; previously sequenced as (EMBL:AF094711), PksC, Streptomyces coelicolor serine/threonine protein kinase (556 aa). Highly similar to SCGD3.21c which lies upstream, on the opposite strand. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain, PS00108 Serine/Threonine protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature. (556 aa)
SCO3848SCH69.18, possible serine/threonine protein kinase, len: 673 aa; similar to many e.g. TR:P71584 (EMBL:Z80233) putative serine/threonine protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores; opt: 1185, z-score: 1028.0, E(): 0, (42.0% identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) serine/threonine protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores; opt: 598, z-score: 522.8, E(): 8.6e-22, (33.9% identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores; opt: 1104, z-score: 1039.5, E(): 0, (50.0% ide [...] (673 aa)
SCO4184SCD66.21, amfC, aerial mycelium formation, len: 222 aa; identical to previously sequenced TR:Q54191 (EMBL:D63677) Streptomyces coelicolor aerial micelium formation AmfC, 222 aa. (222 aa)
SCO4501SCD35.08c, probable bifunctional protein (ketoreductase/3-oxoacyl-[acyl-carrier protein] reductase), len: 430 aa; highly similar to TR:O53665 (EMBL:AL021929) Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] reductase MTV034.08c, 454 aa; fasta scores: opt: 1227 z-score: 1186.5 E(): 0; 50.8% identity in 455 aa overlap, N-terminal region similar to TR:O86480 (EMBL:AJ007932) Streptomyces argillaceus ketoreductase MtmTII, 253 aa; blastp results: Identities = 54/204 (26%), Positives = 87/204 (42%) and C-terminal region to SW:FABG_ECOLI (EMBL:M84991) Escherichia coli 3-oxoacyl-[acy [...] (430 aa)
SCO4681SCD31.06, probable short chain dehydrogenase, len: 296 aa; similar to TR:CAB56135 (EMBL:AL117669) Streptomyces coelicolor putative short chain dehydrogenase SCF12.09, 249 aa; fasta scores: opt: 1003 z-score: 1070.0 E(): 0; 65.2% identity in 244 aa overlap and to SW:SDR1_PICAB (EMBL:X74115) Picea abies short-chain type dehydrogenase/reductase (EC 1.-.-.-) Sdr1,271 aa; fasta scores: opt: 576 z-score: 619.1 E(): 4.7e-27; 47.8% identity in 251 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reduct [...] (269 aa)
SCO4775SCD63.07, pkaH, serine/threonine protein kinase, len: 717 aa; similar to TR:Q9XAI1 (EMBL:AL079348) Streptomyces coelicolor putative serine/threonine protein kinase SC66T3.32c, 783 aa; fasta scores: opt: 570 z-score: 386.8 E(): 4.1e-14; 30.6% identity in 687 aa overlap and to SW:PKAA_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaA (EC 2.7.1.-), 543 aa; fasta scores: opt: 543 z-score: 370.9 E(): 3.1e-13; 29.8% identity in 476 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 P [...] (717 aa)
SCO4777SCD63.09, pkaD, protein serine/threonine kinase, len: 599 aa; identical to previously sequenced TR:O83032 (EMBL:AB016932) Streptomyces coelicolor protein serine/threonine kinase PkaD. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Serine/Threonine protein kinases active-site signature and possible hydrophobic membrane spanning region. (599 aa)
SCO5003SCK15.05c, chiA, chinitase A precursor, len: 571 aa; identical to previously sequenced TR:Q9Z9M9 (EMBL:AB017008) Streptomyces coelicolor chinitase A precursor ChiA, 571 aa and to TR:Q59924 (EMBL:D13775) Streptomyces lividans chitinase A precursor (EC 3.2.1.14) ChiA, 571 aa. Contains Pfam match to entry PF02018 CBD_6, Cellulose binding domain, PF00041 fn3, Fibronectin type III domain, PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18 and matches to Prosite entries PS00678 Trp-Asp (WD) repeats signature and PS01095 Chitinases family 18 active site. Contains also possible N-terminal r [...] (571 aa)
SCO5112SCBAC31E11.08, bldKA, possible ABC transport system integral membrane protein, len: 343 aa; identical to previously sequenced TR:P72406 (EMBL:U68036) Streptomyces coelicolor BldKA, 335 aa. Methionine start codon 9 amino acids upstream from the previous sequence start; possible frameshift from frame 2 into frame 1 in the previously sequenced DNA. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possibl [...] (343 aa)
SCO53762SC6G5.20c, chiC, chitinase C (EC 3.2.1.14) (putative secreted protein), len: 609aa; previously sequenced as TR:Q9Z9M8 (EMBL:AB017010). Strongly similar to others from Streptomyces spp. e.g. SW:P11220 (CHIT_STRPL) chitinase 63 precursor from Streptomyces plicatus (610 aa) fasta scores; opt: 3997, z-score: 3833.9, E(): 0, 95.1% identity in 611 aa overlap. Contains Pfam match to entry PF00704 Glyco_hydro_18, Glycosyl hydrolases family 18, Pfam match to entry PF00041 fn3, Fibronectin type III domain, Pfam match to entry PF00553 CBD_2, Cellulose binding domain, Prosite match to PS00561 Cel [...] (609 aa)
SCO5621RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (280 aa)
SCO5723SC3C3.09c, possible regulator, BldB, len: 98 aa; identical to TR:Q53842 (EMBL:U28930) bldB (98 aa) and similar to S. coelicolor TR:Q53896 (EMBL:X60316) AbaA ORFD (75 aa), fasta scores; opt: 150 z-score: 201.9 E(): 0.00055, 47.4% identity in 57 aa overlap. (98 aa)
SCO5793Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
SCO6249SCAH10.14c, probable 3-oxoacyl-[acyl-carrier-protein] reductase, len: 258 aa; similar to TR:CAB42951 (EMBL:AL049863) Streptomyces coelicolor putative dehydrogenase/reductase, SC5H1.26, 245 aa; fasta scores: opt: 560 z-score: 573.5 E(): 1.4e-24; 45.1% identity in 246 aa overlap and to SW:FABG_BACSU (EMBL:U59433) Bacillus subtilis, 3-oxoacyl-[acyl-carrier-protein] reductase, FabG 246 aa; fasta scores: opt: 471 z-score: 484.6 E(): 1.3e-19; 36.0% identity in 247 aa overlap. (258 aa)
SCO6264Reductase; SCAH10.29, reductase orfX, len: 262 aa; identical to previously sequenced TR:O86853 (EMBL:AJ007731) Streptomyces coelicolor 3-ketoacyl-ACP/CoA reductase, 244 aa and to SW:VER1_ASPPA (EMBL:M91369) Aspergillus parasiticus versicolor reductase (EC 1.1.-.-)(ver-1) 262 aa; fasta scores opt: 571 z-score: 634.6 E(): 5.7e-28; 40.9% identity in 259 aa overlap. Contains match to Pfam entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases famil [...] (262 aa)
SCO7240SC7A12.07, possible serine/threonine-protein kinase, len: 745 aa. Similar to many kinases including: Myxococcus xanthus SW:PKN2_MYXXA (EMBL:M94857) serine/threonine-protein kinase (EC 2.7.1.-) (830 aa), fasta scores opt: 653 z-score: 572.5 E(): 2e-24 31.1% identity in 636 aa overlap and Streptomyces coelicolor TR:Q9XA57(EMBL:AL096822) putative serine/threonine protein kinase, SCGD3.21C (522 aa), fasta scores opt: 700 z-score: 615.9 E(): 7.7e-27 37.1% identity in 407 aa overlap. Contains a Prosite hit to PS00107 Protein kinases ATP-binding region signature and a Pfam match to entry PF00 [...] (745 aa)
SCO7266SC5H1.26, probable 3-oxoacyl-[acyl-carrier protein] reductase, len: 245 aa; similar to many short-chain oxidoreductases e.g. SW:FABG_BACSU (EMBL:U59433), FabG, Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase (246 aa), fasta scores; opt: 521 z-score: 562.5 E(): 5.2e-24, 36.6% identity in 246 aa overlap and SW:DHG2_BACME (EMBL:D90044), GdhII, Bacillus megaterium glucose 1-dehydrogenase II (261 aa) (35.3% identity in 249 aa overlap). Similar to SCE134.03c (EMBL:AL049661) possible short chain dehydrogenase (255 aa) (35.1% identity in 242 aa overlap). Contains Pfam matches to e [...] (245 aa)
SCO1489SC9C5.13, bldD, putative DNA-binding protein, len: 167 aa; identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor putative DNA binding protein BldD, 167 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (167 aa)
SCO3549Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity). (113 aa)
SCO3543Probable DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] (952 aa)
SCO3502SCE134.03c, possible 3-oxoacyl-[acyl carrier protein] reductase, len: 255 aa; similar to many e.g. SW:FABG_BACSU 3-oxoacyl-[acyl carrier protein] reductase from Bacillus subtilis (246 aa) fasta scores; opt: 522, z-score: 518.3, E(): 1.5e-21, (38.1% identity in 247 aa overlap). Contains Pfam matches to entries PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and PF00106 adh_short, short chain dehydrogenase. (255 aa)
SCO2792SCC105.23, adpA, araC-family transcriptional regulator, len: 398 aa; highly similar to TR:BAA86265 (EMBL:AB023785) Streptomyces griseus AdpA, 405 aa; fasta scores: opt: 2219 z-score: 2270.5 E(): 0; 84.4% identity in 410 aa overlap and to TR:Q9XA73 (EMBL:AL096822) Streptomyces coelicolor putative araC-family transcriptional regulator SCGD3.05, 334 aa; fasta scores: opt: 878 z-score: 904.2 E(): 0; 45.7% identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS00041 Bacterial regulat [...] (398 aa)
SCO2110SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...] (667 aa)
SCO13462SCG61.28c, fabG3, possible 3-oxoacyl-[acyl-carrier protein] reductase, len: 253 aa; similar to many eg. SW:P25716 (FABG_ECOLI) 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) from Escherichia coli (244 aa) fasta scores; opt: 624, z-score: 674.0, E(): 4.5e-30, 40.5% identity in 247 aa overlap. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus, Pfam match to entry PF00106 adh_short, short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. (253 aa)
SCO0330SCF12.09, probable short chain oxidoreductase, len: 249 aa; similar to many eg. TR:O86853 (EMBL:AJ007731) 3-ketoacyl-ACP/CoA reductase from Streptomyces coelicolor (244 aa) fasta scores; opt: 515, z-score: 576.2, E(): 9.6e-25, (40.2% identity in 244 aa overlap and to SW:FABG_BACSU (EMBL:U59433) Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) FabG, 246 aa; fasta scores: opt: 473 Z-score: 524.5 E(): 1.4e-21; 37.500% identity in 248 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase; Pfam match to entry PF00678 adh_short_C2, S [...] (249 aa)
SCO1950Hypothetical protein; Involved in cell division and chromosome segregation (By similarity). Involved in sporulation. May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation. Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB. Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner ; Be [...] (328 aa)
SCO1831SCI8.16, possible oxidoreductase, len: 251 aa. Similar to several including Streptomyces coelicolor TR:CAB52925 (EMBL: AL109949) putative oxidoreductase SCJ11.40 (250 aa), fasta scores opt: 462 z-score: 489.9 E(): 6.4e-20 33.9% identity in 248 aa overlap and Bacillus megaterium SW:DHG2_BACME (EMBL: D90044) glucose 1-dehydrogenase II (EC 1.1.1.47) (GLCDH-II) (261 aa), fasta scores opt: 412 z-score: 437.9 E(): 5e-17 34.6% identity in 254 aa overlap. Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C- [...] (251 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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