STRINGSTRING
SCO0386 SCO0386 SCO1204 SCO1204 SCO1254 SCO1254 SCO1483 SCO1483 SCO1484 SCO1484 SCO1487 SCO1487 SCO1570 SCO1570 SCO1613 SCO1613 SCO1773 SCO1773 SCO1977 SCO1977 SCO2025 SCO2025 SCO2026 SCO2026 SCO2198 SCO2198 SCO2210 SCO2210 SCO2241 SCO2241 SCO2789 SCO2789 SCO2999 SCO2999 SCO3382 SCO3382 SCO3416 SCO3416 SCO3629 SCO3629 SCO4078 SCO4078 SCO4086 SCO4086 SCO4645 SCO4645 SCO4683 SCO4683 SCO4740 SCO4740 SCO4780 SCO4780 SCO4984 SCO4984 SCO5520 SCO5520 SCO5676 SCO5676 SCO6222 SCO6222 SCO6412 SCO6412 SCO6962 SCO6962 SCO7034 SCO7034 SCO7035 SCO7035 SCO7036 SCO7036 SCO7049 SCO7049
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0386SCF62.12, putative asparagine synthetase, len: 644 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:ASNH_MYCTU (EMBL; Z70283) putative asparagine synthetase (glutamine-hydrolysing) (EC 6.3.5.4) (652 aa), fasta scores opt: 752 z-score: 874.8 E():0 32.8% identity in 655 aa overlap. Contains a Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. (644 aa)
SCO12042SCG58.04, probable aldehyde dehydrogenase, len: 461 aa; similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD, 482 aa; fasta scores: opt: 1006 z-score: 1146.9 E(): 0; 36.5% identity in 455 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. (461 aa)
SCO12542SCG18.01, purB, probable adenylosuccino lyase (fragment), len: >362 aa; highly similar to TR:Q9RHX3 (EMBL:AB00316) Corynebacterium ammoniagenes adenylosuccino lyase PurB, 479 aa; fasta scores: opt: 1625 z-score: 1824.6 E(): 0; 69.4% identity in 363 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase and match to Prosite entry PS00163 Fumarate lyases signature; 2SCG1.29, purB, adenylosuccino lyase (fragment), len: >149 aa; highly similar to TR:Q9RHX3 (EMBL:AB003161) Corynebacterium ammoniagenes adenylosuccino lyase PurB, 479 aa; fasta scores: opt: 661 z-score: 805.9 E(): 0; [...] (480 aa)
SCO1483SC9C5.07c, pyrA, carbamoylphosphate synthetase large chain, len: 1102 aa; similar to SW:CARB_ECOLI (EMBL:V01500) Escherichia coli carbamoyl-phosphate synthase large chain (EC 6.3.5.5) CarB or PyrA, 1072 aa; fasta scores: opt: 3383 z-score: 3699.6 E(): 0; 55.0% identity in 1102 aa overlap. Contains 3x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and matches to Prosite entries 2x PS00866 Carbamoyl-phosphate synthase subdomain signature 1 and 2x PS00867 Carbamoyl-phosphate synthase subdomain signature. (1102 aa)
SCO1484SC9C5.08c, pyrAA, carbamoyl-phosphate synthase, pyrimidine-specific, small chain, len: 380 aa; similar to SW:CARA_BACCL (EMBL:X73308) Bacillus caldolyticus carbamoyl-phosphate synthase, pyrimidine-specific, small chain (EC 6.3.5.5) PyrAA, 364 aa; fasta scores: opt: 826 z-score: 913.3 E(): 0; 45.3% identity in 362 aa overlap. Contains Pfam matches to entries PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain and PF00117 GATase, Glutamine amidotransferase class-I and match to Prosite entry PS00442 Glutamine amidotransferases class-I active site; Belongs to t [...] (380 aa)
SCO1487SC9C5.11c, pyrB, aspartate carbamoyltransferase, len: 326 aa; similar to SW:PYRB_PSEPU (EMBL:M97253) Pseudomonas putida aspartate carbamoyltransferase (EC 2.1.3.2) PyrB, 334 aa; fasta scores: opt: 902 z-score: 1064.2 E(): 0; 47.3% identity in 311 aa overlap. Contains 2x Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase and match to Prosite entry PS00097 Aspartate and ornithine carbamoyltransferases signature; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (326 aa)
SCO1570SCL24.06c, argH, argininosuccinate lyase, len: 475 aa; highly similar to SW:ARLY_CORGL (EMBL:AF049897) Corynebacterium glutamicum argininosuccinate lyase (EC 4.3.2.1) ArgH, 478 aa; fasta scores: opt: 1473 z-score: 1658.6 E(): 0; 59.1% identity in 391 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase and two matches to Prosite entries PS00163 Fumarate lyases signature and PS00017 ATP/GTP-binding site motif A (P-loop). (475 aa)
SCO1613SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39. (462 aa)
SCO1773SCI51.13c, probable L-alanine dehydrogenase, len: 371 aa; similar to many alanine dehydrogenases e.g. SW:DHA_MYCTU (EMBL:X63069), ald, Mycobacterium tuberculosis L-alanine dehydrogenase (371 aa), fasta scores; opt: 1569 z-score: 1722.1 E(): 0, 65.8% identity in 371 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase and PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. (371 aa)
SCO1977SC3C9.12c, possible glutamate synthase small subunit, len: 496 aa; similar to C-terminal part of SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa glutamate synthase [NADH], chloroplast precursor (EC 1.4.1.14) (NADH-GOGAT) GlsN, 2194 aa; fasta scores: opt: 1473 Z-score: 1543.9 bits: 297.3 E(): 2.2e-78; 47.551% identity in 490 aa overlap and to TR:Q9S2Z0 (EMBL:AL109849) Streptomyces coelicolor putative glutamate synthase small subunit SC3A3.03c, 487 aa; fasta scores: opt: 2145 Z-score: 2259.1 bits: 427.5 E(): 3.2e-118; 66.398% identity in 497 aa overlap. Contains Pfam match to entry PF00070 p [...] (496 aa)
SCO2025SC3A3.03c, gltD, probable glutamate synthase small subunit, len: 487 aa; similar to bacterial glutamate synthases e.g. TR:Q51584 (EMBL:D85230), gltD, Plectonema boryanum small subunit of NADH-dependent glutamate synthase (492 aa), fasta scores; opt: 1295 z-score: 1405.0 E(): 0, 51.2% identity in 500 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.1% identity in 489 aa overlap). Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulf [...] (487 aa)
SCO2026SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap). (1514 aa)
SCO2198Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
SCO2210SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa)
SCO2241SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature. (453 aa)
SCO2789Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
SCO2999SCE33.01c, hypothetical protein (fragment), len: >187 aa; similar to TR:Q9X7B2 (EMBL:AL049913) Mycobacterium leprae hypothetical 177.9 kD protein MCLB1610.10, 1622 aa; fasta scores: opt: 154 z-score: 172.5 E(): 0.038; 29.7% identity in 155 aa overlap; SCE99.06c, conserved hypothetical protein (fragment), len: >1515 aa; similar to TR:AAG06456 (EMBL:AE004731) Pseudomonas aeruginosa conserved hypothetical protein PA3068, 1620 aa; fasta scores: opt: 4170 z-score: 4589.7 E(): 0; 46.3% identity in 1521 aa overlap. (1653 aa)
SCO3382L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (580 aa)
SCO3416SCE9.23, gad, probable glutamate decarboxylase, len: 475 aa; similar to many e.g. SW:DCEA_ECOLI (EMBL:M84024), gadA, Escherichia coli glutamate decarboxylase alpha (466 aa), fasta scores; opt: 1433 z-score: 1665.2 E(): 0, 50.0% identity in 426 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain, score 276.70, E-value 1.1e-79; Belongs to the group II decarboxylase family. (475 aa)
SCO3629Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
SCO4078Phosphoribosyl formylglycinamidine synthase I (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (226 aa)
SCO4086Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (530 aa)
SCO4645SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (408 aa)
SCO4683SCD31.08, gdhA, NADP-specific glutamate dehydrogenase, len: 461 aa; similar to TR:O87403 (EMBL:AF056335) Bacillus licheniformis NADP-specific glutamate dehydrogenase (EC 1.4.1.4) GdhA, 460 aa; fasta scores: opt: 1759 z-score: 1940.3 E(): 0; 59.1% identity in 435 aa overlap and to SW:DHE4_ECOLI (EMBL:J01615) Escherichia coli NADP-specific glutamate dehydrogenase (EC 1.4.1.4) GdhA, 447 aa; fasta scores: opt: 1683 z-score: 1856.8 E(): 0; 58.7% identity in 446 aa overlap. Contains Pfam match to entry PF00208 GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase and match to P [...] (461 aa)
SCO4740Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (615 aa)
SCO4780SCD63.12, probable aldehyde dehydrogenase, len: 537 aa; similar to SW:DHAB_BACSU (EMBL:U47861) Bacillus subtilis betaine aldehyde dehydrogenase (EC 1.2.1.8) GbsA, 490 aa; fasta scores: opt: 950 z-score: 1089.2 E(): 0; 37.4% identity in 460 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site. (537 aa)
SCO49842SCK36.07c, probable aminotransferase, len: 403 aa; similar to many, e.g. TR:O86587 (EMBL:AL031514) Streptomyces coelicolor putative aminotransferase SC2H4.04c, 402 aa; fasta scores: opt: 1881 Z-score: 2193.7 bits: 414.8 E(): 1.4e-114; 65.920% identity in 402 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferase class-I. (403 aa)
SCO5520SC1C2.01, probable delta-1-pyrroline-5-carboxylate dehydrogenase, partial CDS, len >408 aa; similar to many e.g. TR:O50443 (EMBL:AL010186) delta-1-pyrroline-5-carboxylate dehydrogenase (M. tuberculosis) (543 aa), fasta scores; opt: 1753 z-score: 2214.2 E(): 0, 65.1% identity in 407 aa overlap, and PUT2_HUMAN delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa), fasta scores; opt: 1273 z-score: 1730.4 E(): 0, 48.5% identity in 408 aa overlap. Contains PS00687 and PS00070 Aldehyde dehydrogenases glutamic acid active site and cysteine active site and Pfam match to entry PF00171 aldedh, [...] (546 aa)
SCO5676SC8B7.02, gabT, probable 4-aminobutyrate aminotransferase, len: 444 aa; highly similar to e.g. GABT_ECOLI 4-aminobutyrate aminotransferase (EC 2.6.1.19) (426 aa), fasta s cores; opt: 1194 z-score: 1404.8 E(): 0, 45.5% identity in 424 aa overlap. Contains PS00600 Aminotransferases class-II I pyridoxal-phosphate attachment site and Pfam match to ent ry PF00202 aminotran_3, Aminotransferases class-III pyridox al-phosphate, score 516.20, E-value 5e-179; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
SCO6222SC2H4.04c, probable aminotransferase, len: 402 aa; smilar to many e.g. AAT_BACST aspartate aminotransferase (EC 2.6.1.1) (393 aa), fasta scores; opt: 657 z-score: 607.8 E(): 1.3e-26, 33.9% identity in 386 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I, score 136.00, E-value 6.9e-37. (402 aa)
SCO6412SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...] (427 aa)
SCO6962Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase. (466 aa)
SCO7034SC2C3.01, probable aminotransferase (fragment), len: >275 aa; similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT, 426 aa; fasta scores: opt: 634 z-score: 729.2 E(): 0; 40.8% identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; SC1H10.23, possible aminotransferase, partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine [...] (422 aa)
SCO7035SC2C3.02, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >422 aa; highly similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD, 482 aa; fasta scores: opt: 1329 z-score: 1466.8 E(): 0; 48.9% identity in 415 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site; SC4G1.01, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >90 aa; similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli [...] (479 aa)
SCO7036SC4G1.02, argG, argininosuccinate synthase, len: 481 aa; identical to previously sequenced SW:ASSY_STRCO (EMBL:D00799) Streptomyces coelicolor argininosuccinate synthase (EC 6.3.4.5) ArgG, 480 aa. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase and matches to Prosite entries PS00564 Argininosuccinate synthase signature 1 and PS00565 Argininosuccinate synthase signature 2; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (481 aa)
SCO7049SC4G1.15, probable glutaminase, len: 307 aa; similar to TR:O87405 (EMBL:AF057158) Rhizobium etli glutaminase A, 309 aa; fasta scores: opt: 990 z-score: 1158.2 E(): 0; 52.3% identity in 304 aa overlap and to middle part of SW:GLSK_RAT (EMBL:M65150) Rattus norvegicus glutaminase, kidney isoform precursor (EC 3.5.1.2) GlsK, 647 aa; fasta scores: opt: 577 z-score: 672.7 E(): 5.3e-30; 35.2% identity in 293 aa overlap; Belongs to the glutaminase family. (307 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.