(16 nodes) Amyloid-beta formation, and E2 domain superfamily network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
	I79_001115	Amyloid-like protein 2. (682 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (247 aa)
	I79_005385	Gamma-secretase subunit APH-1B. (219 aa)
	I79_005386	Gamma-secretase subunit APH-1B. (196 aa)
	Ncstn	Nicastrin. (615 aa)
	App	Amyloid beta A4 protein. (433 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	I79_012792	Amyloid-like protein 1. (316 aa)
	Tnfrsf21	Tumor necrosis factor receptor superfamily member 21. (654 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	I79_018062	Amyloid beta A4 protein-binding family B member 2. (468 aa)
	I79_020064	Low-density lipoprotein receptor-related protein 3. (767 aa)
	Adam12	Disintegrin and metalloproteinase domain-containing protein 12. (244 aa)
	Apbb2	Amyloid beta A4 protein-binding family B member 2. (234 aa)
	Apbb1	Amyloid beta A4 protein-binding family B member 1. (530 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam10	Adam12	G3GRM2	G3IEN0	Disintegrin and metalloproteinase domain-containing protein 10.	Disintegrin and metalloproteinase domain-containing protein 12.	0.726
Adam10	Aph1a	G3GRM2	G3H2V5	Disintegrin and metalloproteinase domain-containing protein 10.	Gamma-secretase subunit APH-1A.	0.540
Adam10	App	G3GRM2	G3HMG4	Disintegrin and metalloproteinase domain-containing protein 10.	Amyloid beta A4 protein.	0.739
Adam10	I79_001115	G3GRM2	G3GTX5	Disintegrin and metalloproteinase domain-containing protein 10.	Amyloid-like protein 2.	0.463
Adam10	I79_012792	G3GRM2	G3HPS3	Disintegrin and metalloproteinase domain-containing protein 10.	Amyloid-like protein 1.	0.467
Adam10	Ncstn	G3GRM2	G3H7X9	Disintegrin and metalloproteinase domain-containing protein 10.	Nicastrin.	0.847
Adam10	Psen1	G3GRM2	G3HNF2	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.781
Adam10	Psen2	G3GRM2	G3HV76	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.719
Adam12	Adam10	G3IEN0	G3GRM2	Disintegrin and metalloproteinase domain-containing protein 12.	Disintegrin and metalloproteinase domain-containing protein 10.	0.726
Apbb1	Apbb2	G3IMH5	G3IKL4	Amyloid beta A4 protein-binding family B member 1.	Amyloid beta A4 protein-binding family B member 2.	0.469
Apbb1	App	G3IMH5	G3HMG4	Amyloid beta A4 protein-binding family B member 1.	Amyloid beta A4 protein.	0.996
Apbb1	I79_001115	G3IMH5	G3GTX5	Amyloid beta A4 protein-binding family B member 1.	Amyloid-like protein 2.	0.783
Apbb1	I79_012792	G3IMH5	G3HPS3	Amyloid beta A4 protein-binding family B member 1.	Amyloid-like protein 1.	0.790
Apbb1	I79_018062	G3IMH5	G3I3Q2	Amyloid beta A4 protein-binding family B member 1.	Amyloid beta A4 protein-binding family B member 2.	0.478
Apbb2	Apbb1	G3IKL4	G3IMH5	Amyloid beta A4 protein-binding family B member 2.	Amyloid beta A4 protein-binding family B member 1.	0.469
Apbb2	App	G3IKL4	G3HMG4	Amyloid beta A4 protein-binding family B member 2.	Amyloid beta A4 protein.	0.847
Apbb2	I79_001115	G3IKL4	G3GTX5	Amyloid beta A4 protein-binding family B member 2.	Amyloid-like protein 2.	0.570
Apbb2	I79_012792	G3IKL4	G3HPS3	Amyloid beta A4 protein-binding family B member 2.	Amyloid-like protein 1.	0.569
Apbb2	I79_018062	G3IKL4	G3I3Q2	Amyloid beta A4 protein-binding family B member 2.	Amyloid beta A4 protein-binding family B member 2.	0.899
Aph1a	Adam10	G3H2V5	G3GRM2	Gamma-secretase subunit APH-1A.	Disintegrin and metalloproteinase domain-containing protein 10.	0.540