STRINGSTRING
Zbtb7b Zbtb7b Axin1 Axin1 Bmp7 Bmp7 I79_007707 I79_007707 Crebl2 Crebl2 Lrp6 Lrp6 I79_007641 I79_007641 Trib2 Trib2 I79_007629 I79_007629 I79_025994 I79_025994 I79_025745 I79_025745 I79_025549 I79_025549 Prdm16 Prdm16 I79_025027 I79_025027 I79_025026 I79_025026 I79_024997 I79_024997 Zadh2 Zadh2 I79_024533 I79_024533 Tph1 Tph1 I79_024255 I79_024255 I79_024173 I79_024173 Tcf7l2 Tcf7l2 Otogl Otogl I79_022994 I79_022994 I79_022786 I79_022786 Rora Rora I79_022367 I79_022367 Mtor Mtor Alox5 Alox5 Six1 Six1 I79_021840 I79_021840 Sav1 Sav1 H671_3g10030 H671_3g10030 I79_020783 I79_020783 Enpp1 Enpp1 Tgfb1 Tgfb1 Vstm2a Vstm2a I79_020064 I79_020064 Trib3 Trib3 Mybphl Mybphl Wnt10b Wnt10b Wnt1 Wnt1 Fermt2 Fermt2 Znf385a Znf385a I79_018885 I79_018885 Nr1d1 Nr1d1 I79_018750 I79_018750 Aamdc Aamdc Lrp5 Lrp5 Tlcd3b Tlcd3b Htr2a Htr2a I79_018131 I79_018131 Runx1t1 Runx1t1 I79_011789 I79_011789 Tfe3 Tfe3 Hdac6 Hdac6 Xbp1 Xbp1 I79_013013 I79_013013 ATAT1 ATAT1 Snai2 Snai2 Taf8 Taf8 I79_013531 I79_013531 I79_013556 I79_013556 Ppard Ppard I79_013817 I79_013817 I79_014045 I79_014045 Bbs12 Bbs12 Mex3c Mex3c I79_014474 I79_014474 I79_014483 I79_014483 Gper1 Gper1 Noct Noct E2f1 E2f1 I79_007470 I79_007470 Sirt1 Sirt1 Lmo3 Lmo3 Sh3pxd2b Sh3pxd2b I79_006981 I79_006981 I79_006895 I79_006895 Smad3 Smad3 I79_006693 I79_006693 I79_006675 I79_006675 Wnt5b Wnt5b Axin2 Axin2 Hnrnpu Hnrnpu Lpl Lpl Fndc3b Fndc3b I79_005864 I79_005864 Igf1 Igf1 I79_005573 I79_005573 Klf5 Klf5 Mkx Mkx Akt1 Akt1 Zfp36l1 Zfp36l1 Msx2 Msx2 I79_003729 I79_003729 Wdfy2 Wdfy2 Lep Lep Gps2 Gps2 I79_002654 I79_002654 Asxl2 Asxl2 Ptgs2 Ptgs2 Medag Medag Ccdc3 Ccdc3 I79_001484 I79_001484 Wnt5a Wnt5a Gnb3 Gnb3 Jag1 Jag1 I79_000238 I79_000238 Dusp10 Dusp10 Gata3 Gata3 Ncor2 Ncor2 I79_015503 I79_015503 Sod2 Sod2 PPARG PPARG Ddit3 Ddit3 Cmklr1 Cmklr1 Ccdc85b Ccdc85b I79_017450 I79_017450 Zbtb16 Zbtb16 I79_017381 I79_017381 Gdf3 Gdf3 Htr2c Htr2c Dkkl1 Dkkl1 Trpm4 Trpm4 Foxo1 Foxo1 Mapk14 Mapk14 Tnf Tnf I79_016386 I79_016386 Napepld Napepld Dlk2 Dlk2 Adipoq Adipoq I79_016044 I79_016044 Alms1 Alms1 Wwtr1 Wwtr1 Dlk1 Dlk1 Mmp11 Mmp11 Stk4 Stk4 Ankrd30a Ankrd30a Pim1 Pim1 Stk3 Stk3 Zfp36 Zfp36 Sirt2 Sirt2 Gata2 Gata2 Trpv4 Trpv4 I79_010314 I79_010314 I79_010136 I79_010136 Sfrp1 Sfrp1 I79_009431 I79_009431 I79_009001 I79_009001 Asxl1 Asxl1 Zc3h12a Zc3h12a Rreb1 Rreb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Zbtb7bZinc finger and BTB domain-containing protein 7B. (543 aa)
Axin1Axin-1. (863 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
I79_007707Retinoic acid receptor responder protein 2. (144 aa)
Crebl2cAMP-responsive element-binding protein-like 2. (79 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (565 aa)
I79_007641Low-density lipoprotein receptor-related protein 6. (543 aa)
Trib2Tribbles-like 2. (291 aa)
I79_007629Lipin-1. (895 aa)
I79_025994WNT1-inducible-signaling pathway protein 1. (136 aa)
I79_025745Nuclear receptor subfamily 1 group D member 1. (226 aa)
I79_025549WNT1-inducible-signaling pathway protein 1. (274 aa)
Prdm16PR domain zinc finger protein 16. (274 aa)
I79_025027PR domain zinc finger protein 16. (86 aa)
I79_025026PR domain zinc finger protein 16. (409 aa)
I79_024997Ankyrin repeat domain-containing protein 26. (238 aa)
Zadh2Zinc-binding alcohol dehydrogenase domain-containing protein 2. (126 aa)
I79_024533Tryptophan 5-hydroxylase 1. (131 aa)
Tph1Tryptophan 5-hydroxylase 1. (115 aa)
I79_024255Galectin. (284 aa)
I79_024173PR domain zinc finger protein 16. (77 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
OtoglPhosphotidylinositol phosphatase PTPRQ. (360 aa)
I79_022994Dapper-like 1. (530 aa)
I79_022786Ankyrin repeat domain-containing protein 26. (249 aa)
RoraNuclear receptor ROR-alpha. (959 aa)
I79_022367Nucleobindin-2. (420 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
Alox5Arachidonate 5-lipoxygenase. (674 aa)
Six1Homeobox protein SIX1. (284 aa)
I79_021840Nuclear receptor ROR-gamma. (341 aa)
Sav1Protein salvador-like 1. (210 aa)
H671_3g10030Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (204 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Vstm2aV-set and transmembrane domain-containing protein 2A. (236 aa)
I79_020064Low-density lipoprotein receptor-related protein 3. (767 aa)
Trib3Tribbles-like 3. (353 aa)
MybphlProteasome endopeptidase complex. (1190 aa)
Wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Fermt2Fermitin family-like 2. (575 aa)
Znf385aZinc finger protein 385A. (366 aa)
I79_018885Transmembrane protein 64. (105 aa)
Nr1d1Nuclear receptor subfamily 1 group D member 1. (508 aa)
I79_018750Phosphatidate cytidylyltransferase; Belongs to the CDS family. (367 aa)
AamdcUPF0366 protein C11orf67-like. (109 aa)
Lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
Tlcd3bProtein FAM57B. (275 aa)
Htr2a5-hydroxytryptamine receptor 2A. (264 aa)
I79_0181315-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (237 aa)
Runx1t1Protein CBFA2T1. (498 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
Tfe3Transcription factor E3. (574 aa)
Hdac6Histone deacetylase 6. (666 aa)
Xbp1X-box binding protein 1 isoform 1. (330 aa)
I79_013013Transcription factor SOX-13. (600 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (395 aa)
Snai2Zinc finger protein SNAI2-like protein. (268 aa)
Taf8Transcription initiation factor TFIID subunit 8. (308 aa)
I79_013531Ankyrin repeat domain-containing protein 26. (390 aa)
I79_013556Fibrillin-1. (2698 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
I79_013817NAD-dependent deacetylase sirtuin-6. (334 aa)
I79_014045Ankyrin repeat domain-containing protein 26. (102 aa)
Bbs12Bardet-Biedl syndrome 12 protein-like. (700 aa)
Mex3cRNA-binding protein MEX3C. (358 aa)
I79_014474Cyclic AMP-responsive element-binding protein 1. (325 aa)
I79_014483Serine/threonine-protein kinase 3. (118 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
NoctNocturnin. (365 aa)
E2f1Transcription factor E2F1. (367 aa)
I79_007470Triple functional domain protein. (497 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Lmo3LIM domain only protein 3. (149 aa)
Sh3pxd2bSH3 and PX domain-containing protein 2B. (880 aa)
I79_006981G-protein coupled receptor 120. (318 aa)
I79_006895Fibronectin type III domain-containing protein 5. (244 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
I79_006693Intraflagellar transport protein 88-like. (533 aa)
I79_006675Secreted frizzled-related protein 3. (286 aa)
Wnt5bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
Axin2Axin-2. (809 aa)
HnrnpuHeterogeneous nuclear ribonucleoprotein U. (512 aa)
LplLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
Fndc3bFibronectin type III domain-containing protein 3B. (1203 aa)
I79_005864Histone-arginine methyltransferase CARM1. (94 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_005573Secreted frizzled-related protein 2. (268 aa)
Klf5Krueppel-like factor 5. (366 aa)
MkxHomeobox protein Mohawk. (352 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Zfp36l1Butyrate response factor 1. (338 aa)
Msx2Homeobox protein MSX-2. (267 aa)
I79_003729Protein fto. (502 aa)
Wdfy2WD repeat and FYVE domain-containing protein 2. (372 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Gps2G protein pathway suppressor 2. (327 aa)
I79_002654Wnt inhibitory factor 1. (347 aa)
Asxl2Putative Polycomb group protein ASXL2. (1421 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
MedagMEDAG. (303 aa)
Ccdc3Coiled-coil domain-containing protein 3. (272 aa)
I79_00148465 kDa Yes-associated protein. (257 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
Gnb3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (227 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
I79_000238Zinc finger protein ZFPM1. (744 aa)
Dusp10Dual specificity protein phosphatase 10. (482 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
Ncor2Nuclear receptor corepressor 2. (2530 aa)
I79_015503Transcription factor HES-1. (92 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Ddit3DNA damage-inducible transcript 3. (167 aa)
Cmklr1Chemokine receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
Ccdc85bCoiled-coil domain-containing protein 85B. (202 aa)
I79_017450Zinc finger and BTB domain-containing protein 16. (236 aa)
Zbtb16Zinc finger and BTB domain-containing protein 16. (423 aa)
I79_017381Synapse-associated protein 1. (313 aa)
Gdf3Growth/differentiation factor 3. (361 aa)
Htr2c5-hydroxytryptamine receptor 2C. (317 aa)
Dkkl1Dickkopf-like protein 1. (230 aa)
Trpm4Transient receptor potential cation channel subfamily M member 4. (315 aa)
Foxo1Forkhead box protein O1. (469 aa)
Mapk14Mitogen-activated protein kinase. (349 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
I79_016386Phosphotidylinositol phosphatase PTPRQ. (243 aa)
NapepldN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D. (236 aa)
Dlk2Protein delta-like 2. (382 aa)
AdipoqAdiponectin. (248 aa)
I79_016044Alstrom syndrome protein 1-like. (276 aa)
Alms1Alstrom syndrome protein 1-like. (327 aa)
Wwtr1WW domain-containing transcription regulator protein 1. (395 aa)
Dlk1Protein delta-like 1. (361 aa)
Mmp11Stromelysin-3. (361 aa)
Stk4Serine/threonine-protein kinase 4. (487 aa)
Ankrd30aAnkyrin repeat domain-containing protein 26. (1699 aa)
Pim1Proto-oncogene serine/threonine-protein kinase Pim-1. (250 aa)
Stk3Serine/threonine-protein kinase 3. (260 aa)
Zfp36Tristetraproline. (315 aa)
Sirt2NAD-dependent deacetylase sirtuin-2. (83 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
Trpv4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
I79_010314Ecotropic virus integration site 1 protein. (947 aa)
I79_010136Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
Sfrp1Secreted frizzled-related protein 1. (104 aa)
I79_009431Jun dimerization protein 2. (162 aa)
I79_009001Zinc finger protein ZFPM2. (718 aa)
Asxl1Putative Polycomb group protein ASXL1. (1470 aa)
Zc3h12aRibonuclease ZC3H12A. (577 aa)
Rreb1Ras-responsive element-binding protein 1. (1748 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.