(76 nodes) Nephron morphogenesis network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fat4	Protocadherin Fat 4. (5152 aa)
	Npm3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	I79_015321	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (243 aa)
	I79_015033	Hairy/enhancer-of-split related with YRPW motif protein 1. (199 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Smad4	Mothers against decapentaplegic-like 4. (259 aa)
	I79_021155	Paired box protein Pax-2. (503 aa)
	Grem1	Gremlin-1. (117 aa)
	I79_021721	Protocadherin-16. (3015 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	Pax8	Paired box protein Pax-8. (452 aa)
	Lgr4	Leucine-rich repeat-containing G-protein coupled receptor 4. (231 aa)
	I79_022733	Kelch-like protein 3. (427 aa)
	I79_023900	Leucine zipper putative tumor suppressor 2. (449 aa)
	I79_024070	Heparan sulfate 2-O-sulfotransferase 1. (224 aa)
	Ptch1	Protein patched-like 1. (1114 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Six2	Homeobox protein SIX2. (299 aa)
	Ahi1	Jouberin. (988 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	I79_003731	Iroquois-class homeodomain protein IRX-3. (341 aa)
	Nog	Noggin. (117 aa)
	I79_005331	Receptor tyrosine-protein kinase erbB-4. (480 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_006364	Kinesin-like protein KIF26B. (158 aa)
	Kif26b	Kinesin-like protein KIF26B. (189 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Lhx1	LIM/homeobox protein Lhx1. (84 aa)
	I79_007089	Receptor tyrosine-protein kinase erbB-4. (225 aa)
	I79_007090	Receptor tyrosine-protein kinase erbB-4. (182 aa)
	Greb1	Protein GREB1. (1972 aa)
	Bmp7	Bone morphogenetic protein 7. (430 aa)
	Pkd1	Polycystin-1. (3717 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	CgPICR_019990	Persephin. (157 aa)
	Hoxa11	Homeobox protein Hox-A11. (250 aa)
	Osr1	Protein odd-skipped-related 1. (266 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	Pgf	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
	I79_009699	GREB1-like protein. (1598 aa)
	I79_009708	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (332 aa)
	Lama5	Laminin subunit alpha-5. (3735 aa)
	Fmn1	Formin-1. (644 aa)
	I79_010448	Formin-1. (1049 aa)
	Wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
	Gdnf	Glial cell line-derived neurotrophic factor. (160 aa)
	Pbx1	Pre-B-cell leukemia transcription factor 1. (325 aa)
	I79_011731	Serine/threonine-protein kinase WNK4. (1139 aa)
	I79_012727	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (441 aa)
	Timeless	Protein timeless-like. (1200 aa)
	I79_013660	Beta-type platelet-derived growth factor receptor. (454 aa)
	Pdgfrb	Beta-type platelet-derived growth factor receptor. (528 aa)
	Ctnnbip1	Beta-catenin-interacting protein 1. (81 aa)
	I79_024483	Polycystin-2. (192 aa)
	Commd5	COMM domain-containing protein 5. (224 aa)
	Dspp	Dentin sialophosphoprotein. (859 aa)
	I79_025625	Polycystin-2. (318 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	I79_019149	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
	Irx2	Iroquois-class homeodomain protein IRX-2. (211 aa)
	Irx1	Iroquois-class homeodomain protein IRX-1. (319 aa)
	Tcf21	Transcription factor 21. (179 aa)
	Tacstd2	Tumor-associated calcium signal transducer 2-like protein. (318 aa)
	Hnf1b	Hepatocyte nuclear factor 1-beta. (593 aa)
	Gzf1	GDNF-inducible zinc finger protein 1. (701 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp7	Ctnnb1	G3HBL1	G3H996	Bone morphogenetic protein 7.	Catenin beta-1.	0.401
Bmp7	Fgf1	G3HBL1	G3HEK8	Bone morphogenetic protein 7.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.458
Bmp7	Grem1	G3HBL1	G3ID48	Bone morphogenetic protein 7.	Gremlin-1.	0.936
Bmp7	I79_006225	G3HBL1	G3H796	Bone morphogenetic protein 7.	Sonic hedgehog protein.	0.444
Bmp7	I79_006254	G3HBL1	G3H7C4	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.808
Bmp7	Nog	G3HBL1	G3H1C7	Bone morphogenetic protein 7.	Noggin.	0.996
Bmp7	Smad4	G3HBL1	G3HTR4	Bone morphogenetic protein 7.	Mothers against decapentaplegic-like 4.	0.634
CgPICR_019990	Gdnf	G3HCK6	G3HJV8	Persephin.	Glial cell line-derived neurotrophic factor.	0.667
Ctnnb1	Bmp7	G3H996	G3HBL1	Catenin beta-1.	Bone morphogenetic protein 7.	0.401
Ctnnb1	Ctnnbip1	G3H996	G3IKH6	Catenin beta-1.	Beta-catenin-interacting protein 1.	0.999
Ctnnb1	Fat4	G3H996	G3I301	Catenin beta-1.	Protocadherin Fat 4.	0.671
Ctnnb1	I79_000973	G3H996	G3GTI9	Catenin beta-1.	Transcription factor SOX-10.	0.781
Ctnnb1	I79_005331	G3H996	G3H4W8	Catenin beta-1.	Receptor tyrosine-protein kinase erbB-4.	0.404
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	I79_006254	G3H996	G3H7C4	Catenin beta-1.	Bone morphogenetic protein 4.	0.448
Ctnnb1	I79_007089	G3H996	G3H9L3	Catenin beta-1.	Receptor tyrosine-protein kinase erbB-4.	0.404
Ctnnb1	I79_007090	G3H996	G3H9L4	Catenin beta-1.	Receptor tyrosine-protein kinase erbB-4.	0.404
Ctnnb1	I79_015321	G3H996	G3HWG4	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.535
Ctnnb1	I79_021721	G3H996	G3IDE3	Catenin beta-1.	Protocadherin-16.	0.607
Ctnnb1	Myc	G3H996	G3IP28	Catenin beta-1.	Myc proto-oncogene protein.	0.673