(18 nodes) Amyloid-beta clearance network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rab11a	Ras-related protein Rab-11A. (216 aa)
	Igf1r	Insulin-like growth factor 1 receptor. (191 aa)
	I79_011940	Platelet glycoprotein 4; Belongs to the CD36 family. (348 aa)
	I79_015046	Low-density lipoprotein receptor. (160 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	Insr	Insulin receptor. (114 aa)
	Picalm	Phosphatidylinositol-binding clathrin assembly protein. (604 aa)
	Cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1960 aa)
	Rab11b	Ras-related protein Rab-11B. (218 aa)
	LDLR	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
	I79_001239	Low-density lipoprotein receptor-related protein 2. (4664 aa)
	Lrpap1	Alpha-2-macroglobulin receptor-associated protein. (351 aa)
	I79_003188	Macrophage scavenger receptor types I and II. (266 aa)
	Ide	Insulin-degrading enzyme; Belongs to the peptidase M16 family. (978 aa)
	Rab5a	Ras-related protein Rab-5A. (215 aa)
	Itgb2	Integrin beta. (769 aa)
	C3	Complement C3. (1626 aa)
	Abca7	ATP-binding cassette sub-family A member 7. (408 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca7	Picalm	G3HF57	G3HXR8	ATP-binding cassette sub-family A member 7.	Phosphatidylinositol-binding clathrin assembly protein.	0.762
C3	Itgb2	G3HCL6	G3H8Z5	Complement C3.	Integrin beta.	0.938
Cltc	I79_001239	G3HJ89	G3GU85	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Low-density lipoprotein receptor-related protein 2.	0.476
Cltc	I79_015046	G3HJ89	G3HVQ6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Low-density lipoprotein receptor.	0.412
Cltc	LDLR	G3HJ89	P35950	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family.	0.412
Cltc	Lrp1	G3HJ89	G3HW34	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Prolow-density lipoprotein receptor-related protein 1.	0.407
Cltc	Picalm	G3HJ89	G3HXR8	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Phosphatidylinositol-binding clathrin assembly protein.	0.937
Cltc	Rab11a	G3HJ89	G3I0B0	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Ras-related protein Rab-11A.	0.606
Cltc	Rab11b	G3HJ89	G3I5Q9	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Ras-related protein Rab-11B.	0.524
Cltc	Rab5a	G3HJ89	G3H8L7	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Ras-related protein Rab-5A.	0.605
I79_001239	Cltc	G3GU85	G3HJ89	Low-density lipoprotein receptor-related protein 2.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.476
I79_001239	Lrpap1	G3GU85	G3GWB3	Low-density lipoprotein receptor-related protein 2.	Alpha-2-macroglobulin receptor-associated protein.	0.514
I79_001239	Picalm	G3GU85	G3HXR8	Low-density lipoprotein receptor-related protein 2.	Phosphatidylinositol-binding clathrin assembly protein.	0.543
I79_003188	I79_011940	G3GZC7	G3HMH7	Macrophage scavenger receptor types I and II.	Platelet glycoprotein 4; Belongs to the CD36 family.	0.512
I79_011940	I79_003188	G3HMH7	G3GZC7	Platelet glycoprotein 4; Belongs to the CD36 family.	Macrophage scavenger receptor types I and II.	0.512
I79_011940	Itgb2	G3HMH7	G3H8Z5	Platelet glycoprotein 4; Belongs to the CD36 family.	Integrin beta.	0.558
I79_011940	Lrp1	G3HMH7	G3HW34	Platelet glycoprotein 4; Belongs to the CD36 family.	Prolow-density lipoprotein receptor-related protein 1.	0.451
I79_011940	Picalm	G3HMH7	G3HXR8	Platelet glycoprotein 4; Belongs to the CD36 family.	Phosphatidylinositol-binding clathrin assembly protein.	0.482
I79_015046	Cltc	G3HVQ6	G3HJ89	Low-density lipoprotein receptor.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.412
I79_015046	Lrpap1	G3HVQ6	G3GWB3	Low-density lipoprotein receptor.	Alpha-2-macroglobulin receptor-associated protein.	0.402