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deoC deoC glpX glpX rbsK rbsK DTL3_0428 DTL3_0428 fba fba pgi pgi mipB mipB scrK scrK zwf zwf nagB1 nagB1 DTL3_0887 DTL3_0887 DTL3_0898 DTL3_0898 fucA1 fucA1 gln gln DTL3_1161 DTL3_1161 xylB2 xylB2 ldhA ldhA yqjI yqjI manA manA apgM apgM fucA3 fucA3 gapA gapA pgk pgk tpiA tpiA rpe rpe pfkA pfkA tktA tktA pfk1 pfk1 pgcA pgcA eno eno pfk3 pfk3 glk glk rpiB rpiB DTL3_1879 DTL3_1879
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (247 aa)
glpXFructose 1,6-bisphosphatase; High confidence in function and specificity; Belongs to the FBPase class 2 family. (340 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (303 aa)
DTL3_0428Fructose-bisphosphate aldolase; High confidence in function and specificity. (276 aa)
fbaFructose-bisphosphate aldolase; High confidence in function and specificity. (312 aa)
pgiGlucose-6-phosphate isomerase; D-glucose 6-phosphate <=> D-fructose 6-phosphate; High confidence in function and specificity; Belongs to the GPI family. (457 aa)
mipBTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (222 aa)
scrKFructokinasae; Fructose and mannose metabolism; High confidence in function and specificity. (317 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (518 aa)
nagB16-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (242 aa)
DTL3_0887Phosphoglucomutase; Alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate; High confidence in function and specificity. (560 aa)
DTL3_0898Sugar kinases, ribokinase family; High confidence in function and specificity. (310 aa)
fucA1L-fuculose-phosphate aldolase; It catalyzes the reaction: L-fuculose 1-phosphate <=> glycerone phosphate + (S)-lactaldehyde; High confidence in function and specificity. (212 aa)
glnNitrogen regulatory protein P-II; P-II modulates the activity of glutamine synthetase; High confidence in function and specificity. (223 aa)
DTL3_1161Hypothetical protein; Function unknown; High confidence in function and specificity. (499 aa)
xylB2D-xylulose kinase (XylB) generally is found with xylose isomerase (XylA) and acts in xylose utilization; High confidence in function and specificity; Belongs to the FGGY kinase family. (497 aa)
ldhALactate dehydrogenase catalyzes the conversion of pyruvate to lactate and back, as it converts NADH to NAD+ and back; High confidence in function and specificity. (343 aa)
yqjI6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
manAMannose-6-phosphate isomerase type I; Is an enzyme which facilitates the interconversion of fructose 6-phosphate(F6P) and mannose-6-phosphate(M6P); High confidence in function and specificity. (269 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (404 aa)
fucA3Class II Aldolase; Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism; High confidence in function and specificity. (198 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; The enzyme is responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pgkPhosphoglycerate kinase; A monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate; High confidence in function and specificity. (399 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (243 aa)
rpeRibulose-phosphate 3-epimerase; PPE converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Calvin's reductive pentose phosphate cycle. It has been found in a wide range of bacteria; High confidence in function and specificity; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)
tktATransketolase; It catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways; High confidence in function and specificity. (631 aa)
pfk16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (407 aa)
pgcAPhosphoglucomutase; Second step of UDP-GlcNAc biosynthesis; High confidence in function and specificity. (582 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
pfk36-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (338 aa)
glkGlucokinase; Kinase (ROK) family regulators that are characterized by carbohydrate-sensing domains shared with sugar kinases; High confidence in function and specificity. (315 aa)
rpiBRibose 5-phosphate isomerase RpiB; Carbohydrate transport and metabolism; High confidence in function and specificity. (147 aa)
DTL3_1879The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, all of which use a nucleophilic aspartate in their phosphoryl transfer reaction; High confidence in function and specificity. (196 aa)
Your Current Organism:
Defluviitoga tunisiensis
NCBI taxonomy Id: 1006576
Other names: D. tunisiensis, DSM 23805, Defluviitoga tunisiensis Ben Hania et al. 2012, JCM 17210, Thermotogaceae bacterium SulfLac1, strain SulfLac1
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